In vivo measurement of regional brain tissue pH using positron emission tomography

In vivo measurement of regional brain tissue pH using positron emission tomography

Carbon‐11‐labeled dimethyloxazolidinedione ([11C]DMO) was injected intravenously into human subjects, and serial positron emission tomographic (PET) scans were obtained until brain‐blood equilibration was achieved or could be accurately predicted from dynamic PET and 11C blood data. Knowledge of reg...

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Veröffentlicht in:Annals of neurology 1984, Vol.15 (S1), p.98-102
Hauptverfasser: Rottenberg, D. A., Ginos, J. Z., Kearfott, K. J., Junck, L., Bigner, D. D.
Format: Artikel
Sprache:eng
Schlagworte:
Brain - diagnostic imaging
Brain Chemistry
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - metabolism
Dimethadione
Humans
Hydrogen-Ion Concentration
Tomography, Emission-Computed
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Zusammenfassung:Carbon‐11‐labeled dimethyloxazolidinedione ([11C]DMO) was injected intravenously into human subjects, and serial positron emission tomographic (PET) scans were obtained until brain‐blood equilibration was achieved or could be accurately predicted from dynamic PET and 11C blood data. Knowledge of regional brain‐blood partition coefficients for DMO, together with measurements of arterial blood hematocrit and pH, permitted the calculation of regional brain tissue and tumor pH (rpH). [11C]DMO PET rpH values were similar to rpH values derived from quantitative autoradiographic measurements of [14C]DMO concentrations in rat brain slices.
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.410150718