In vitro effect of ( E)-5-(2-bromovinyl)-2′-deoxyuridine, 5′-amino-5-iodo-2′,5′-dideoxyuridine and 2-deoxy- d-glucose on latent ganglionic herpes simplex virus infection

( E)-5-(2-Bromovinyl)-2′-deoxyuridine (BVDU) and 5′-amino-5-iodo-2′,5′-dideoxyuridine AIdUrd) blocked the reactivation of latent ganglionic herpes simplex virus in vitro. Furthermore, BVDU, but not AIdUrd, blocked the multiplication of reactivated latent virus and transiently suppressed emergence of...

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Veröffentlicht in:Antiviral research 1984-04, Vol.4 (1), p.53-61
Hauptverfasser: Pavan-Langston, Deborah, Park, No-Hee, De Clercq, Erik
Format: Artikel
Sprache:eng
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Zusammenfassung:( E)-5-(2-Bromovinyl)-2′-deoxyuridine (BVDU) and 5′-amino-5-iodo-2′,5′-dideoxyuridine AIdUrd) blocked the reactivation of latent ganglionic herpes simplex virus in vitro. Furthermore, BVDU, but not AIdUrd, blocked the multiplication of reactivated latent virus and transiently suppressed emergence of reactivated virus from the sensory ganglia after removal of drug from the medium. 2-Deoxy- d-glucose (2-DG) neither prevented the in vitro reactivation of latent virus nor blocked the further multiplication of reactivated latent virus.
ISSN:0166-3542
1872-9096
DOI:10.1016/0166-3542(84)90025-1