The Structure of Rat Preproatrial Natriuretic Factor as Defined by a Complementary DNA Clone
The structure of rat preproatrial natriuretic factor (preproANF) was determined by nucleotide sequence analysis of an ANF complementary DNA clone. PreproANF is composed of a hydrophobic leader segment (20 amino acids), a precursor containing one glycosylation site (106 amino acids), and ANF (24 amin...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1984-07, Vol.225 (4659), p.324-326 |
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| container_issue | 4659 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Seidman, Christine E. Duby, Allan D. Choi, Edmund Graham, Robert M. Haber, Edgar Homcy, Charles Smith, John A. Seidman, J. G. |
| description | The structure of rat preproatrial natriuretic factor (preproANF) was determined by nucleotide sequence analysis of an ANF complementary DNA clone. PreproANF is composed of a hydrophobic leader segment (20 amino acids), a precursor containing one glycosylation site (106 amino acids), and ANF (24 amino acids). Atrial natriuretic factor is located at the carboxyl terminus of the precursor molecule. The human, mouse, and rat genomes each contain a single ANF gene which is highly conserved. |
| doi_str_mv | 10.1126/science.6234658 |
| format | Article |
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The human, mouse, and rat genomes each contain a single ANF gene which is highly conserved.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.6234658</identifier><identifier>PMID: 6234658</identifier><language>eng</language><publisher>United States: The American Association for the Advancement of Science</publisher><subject>amino acid sequence ; Amino acids ; Animals ; Atrial Natriuretic Factor ; atrium ; Base Sequence ; Biochemistry ; Cardiology ; Cardiovascular research ; Cloning, Molecular ; Complementary DNA ; DNA - genetics ; genes ; Grants ; Laboratory rats ; Liver ; Messenger RNA ; Muscle Proteins - genetics ; Natriuresis ; Nucleic Acid Hybridization ; nucleotide sequence ; Nucleotide sequences ; Nucleotides ; Oligonucleotide probes ; Plasmids ; preproatrial natiuretic factor ; Rats ; Rats as laboratory animals</subject><ispartof>Science (American Association for the Advancement of Science), 1984-07, Vol.225 (4659), p.324-326</ispartof><rights>Copyright 1984 The American Association for the Advancement of Science</rights><rights>COPYRIGHT 1984 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1984 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c677t-be3d5529f489e7a3c1ff6932d72cf38d3b832d0e1e6b9f10e73062f4ab2321203</citedby><cites>FETCH-LOGICAL-c677t-be3d5529f489e7a3c1ff6932d72cf38d3b832d0e1e6b9f10e73062f4ab2321203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1693597$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1693597$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6234658$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seidman, Christine E.</creatorcontrib><creatorcontrib>Duby, Allan D.</creatorcontrib><creatorcontrib>Choi, Edmund</creatorcontrib><creatorcontrib>Graham, Robert M.</creatorcontrib><creatorcontrib>Haber, Edgar</creatorcontrib><creatorcontrib>Homcy, Charles</creatorcontrib><creatorcontrib>Smith, John A.</creatorcontrib><creatorcontrib>Seidman, J. G.</creatorcontrib><title>The Structure of Rat Preproatrial Natriuretic Factor as Defined by a Complementary DNA Clone</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The structure of rat preproatrial natriuretic factor (preproANF) was determined by nucleotide sequence analysis of an ANF complementary DNA clone. PreproANF is composed of a hydrophobic leader segment (20 amino acids), a precursor containing one glycosylation site (106 amino acids), and ANF (24 amino acids). Atrial natriuretic factor is located at the carboxyl terminus of the precursor molecule. The human, mouse, and rat genomes each contain a single ANF gene which is highly conserved.</description><subject>amino acid sequence</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Atrial Natriuretic Factor</subject><subject>atrium</subject><subject>Base Sequence</subject><subject>Biochemistry</subject><subject>Cardiology</subject><subject>Cardiovascular research</subject><subject>Cloning, Molecular</subject><subject>Complementary DNA</subject><subject>DNA - genetics</subject><subject>genes</subject><subject>Grants</subject><subject>Laboratory rats</subject><subject>Liver</subject><subject>Messenger RNA</subject><subject>Muscle Proteins - genetics</subject><subject>Natriuresis</subject><subject>Nucleic Acid Hybridization</subject><subject>nucleotide sequence</subject><subject>Nucleotide sequences</subject><subject>Nucleotides</subject><subject>Oligonucleotide probes</subject><subject>Plasmids</subject><subject>preproatrial natiuretic factor</subject><subject>Rats</subject><subject>Rats as laboratory animals</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0s9r2zAUB3AxNrqs7XmXDXTaDp1b_Yhl-5i5a1YISWm7nQZClp8yF9vKJBnW_34KMWsHgQUdhPQ-ekjoi9BbSs4pZeLC6wZ6DeeC8alI8xdoQkmRJgUj_CWaEMJFkpMsfY3eeP9ASKwV_AgdjXyCftz_BHwX3KDD4ABbg29VwDcONs6q4BrV4uV2jsXQaHyldLAOK48vwTQ91Lh6xAqXttu00EEflHvEl8sZLlvbwwl6ZVTr4XScj9G3qy_35ddksZpfl7NFokWWhaQCXqcpK8w0LyBTXFNjRMFZnTFteF7zKo8LAhREVRhKIONEMDNVFeOMxpceow-7vvHSvwbwQXaN19C2qgc7eJlTOhU0z_8LKS8YJ4xGeLaDa9WCbHpjg1N6DT04tX2ZaeL2jPNU0HSrP-3RcdTQNXoP__gPjyLA77BWg_fy-m55qFx9P1R-nh8o8_niuTzbJ7VtW1iDjF9Yrp7ri53WznrvwMiNa7qYB0mJ3GZVjlmVY_jiiffjbwxVB_Vf_1R_t6s_-Bi6p3YxG2mR8T-fbupw</recordid><startdate>19840720</startdate><enddate>19840720</enddate><creator>Seidman, Christine E.</creator><creator>Duby, Allan D.</creator><creator>Choi, Edmund</creator><creator>Graham, Robert M.</creator><creator>Haber, Edgar</creator><creator>Homcy, Charles</creator><creator>Smith, John A.</creator><creator>Seidman, J. G.</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7QL</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19840720</creationdate><title>The Structure of Rat Preproatrial Natriuretic Factor as Defined by a Complementary DNA Clone</title><author>Seidman, Christine E. ; Duby, Allan D. ; Choi, Edmund ; Graham, Robert M. ; Haber, Edgar ; Homcy, Charles ; Smith, John A. ; Seidman, J. 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| ispartof | Science (American Association for the Advancement of Science), 1984-07, Vol.225 (4659), p.324-326 |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | amino acid sequence Amino acids Animals Atrial Natriuretic Factor atrium Base Sequence Biochemistry Cardiology Cardiovascular research Cloning, Molecular Complementary DNA DNA - genetics genes Grants Laboratory rats Liver Messenger RNA Muscle Proteins - genetics Natriuresis Nucleic Acid Hybridization nucleotide sequence Nucleotide sequences Nucleotides Oligonucleotide probes Plasmids preproatrial natiuretic factor Rats Rats as laboratory animals |
| title | The Structure of Rat Preproatrial Natriuretic Factor as Defined by a Complementary DNA Clone |
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