The Structure of Rat Preproatrial Natriuretic Factor as Defined by a Complementary DNA Clone

The Structure of Rat Preproatrial Natriuretic Factor as Defined by a Complementary DNA Clone

The structure of rat preproatrial natriuretic factor (preproANF) was determined by nucleotide sequence analysis of an ANF complementary DNA clone. PreproANF is composed of a hydrophobic leader segment (20 amino acids), a precursor containing one glycosylation site (106 amino acids), and ANF (24 amin...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1984-07, Vol.225 (4659), p.324-326
Hauptverfasser: Seidman, Christine E., Duby, Allan D., Choi, Edmund, Graham, Robert M., Haber, Edgar, Homcy, Charles, Smith, John A., Seidman, J. G.
Format: Artikel
Sprache:eng
Schlagworte:
amino acid sequence
Amino acids
Animals
Atrial Natriuretic Factor
atrium
Base Sequence
Biochemistry
Cardiology
Cardiovascular research
Cloning, Molecular
Complementary DNA
DNA - genetics
genes
Grants
Laboratory rats
Liver
Messenger RNA
Muscle Proteins - genetics
Natriuresis
Nucleic Acid Hybridization
nucleotide sequence
Nucleotide sequences
Nucleotides
Oligonucleotide probes
Plasmids
preproatrial natiuretic factor
Rats
Rats as laboratory animals
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Zusammenfassung:The structure of rat preproatrial natriuretic factor (preproANF) was determined by nucleotide sequence analysis of an ANF complementary DNA clone. PreproANF is composed of a hydrophobic leader segment (20 amino acids), a precursor containing one glycosylation site (106 amino acids), and ANF (24 amino acids). Atrial natriuretic factor is located at the carboxyl terminus of the precursor molecule. The human, mouse, and rat genomes each contain a single ANF gene which is highly conserved.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6234658