Gas chromatographic analysis of urinary tyrosine and phenylalanine metabolites in patients with gastrointestinal disorders

Main urinary bacterial metabolites of phenylalanine (total benzoic and phenylacetic acids) and of tyrosine (total p-hydroxybenzoic acid and p-hydroxyphenylacetic acid) were determined by gas chromatography in controls and patients with cystic ubrosis of the pancreas, coeliac disease, intestinal resection and unclassified enteritis. In various patients, especially in the untreated coeliacs, high amounts of one or more of the abovementioned metabolites were found. In this paper results in controls and patients are presented and discussed.