Nonencapsidated Infectious DNA of Adeno-Satellite Virus in Cells Coinfected with Herpesvirus

Nonencapsidated Infectious DNA of Adeno-Satellite Virus in Cells Coinfected with Herpesvirus

Adeno-associated satellite viruses produce antigen detectable by immunofluorescence but not infectious virus in tissue culture cells coinfected with herpes simplex virus. Analysis of DNA extracts from these infected cells shows that large amounts of infectious satellite virus DNA are produced but no...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1971-09, Vol.173 (4003), p.1243-1245
Hauptverfasser: Boucher, D. Wark, Melnick, Joseph L., Mayor, Heather D.
Format: Artikel
Sprache:eng
Schlagworte:
Adenoviruses
Animals
Antigens
Antigens, Viral - analysis
Artificial satellites
Cells, Cultured
Cellular immunity
DNA
DNA Viruses - analysis
DNA Viruses - immunology
DNA, Viral - analysis
Fluorescence
Fluorescent Antibody Technique
Haplorhini
Herpesviridae
Humans
Kidney
Satellite DNA
Satellite viruses
Viruses
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Zusammenfassung:Adeno-associated satellite viruses produce antigen detectable by immunofluorescence but not infectious virus in tissue culture cells coinfected with herpes simplex virus. Analysis of DNA extracts from these infected cells shows that large amounts of infectious satellite virus DNA are produced but not encapsidated in the system. This result indicates that satellite virus may be defective at the maturation step.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.173.4003.1243