Influence of bile and pancreatic secretions on the size of the intestinal villi in the rat
Along the rat small intestine, the size of the villi gradually decreases from a maximum in the duodenum to less than half of this size in the terminal ileum. In previous work, various villus enlarging and reducing factors present in the intestinal chyme were found to control villus size. A villus en...
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Veröffentlicht in: | American journal of anatomy 1971-10, Vol.132 (2), p.167-177 |
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Zusammenfassung: | Along the rat small intestine, the size of the villi gradually decreases from a maximum in the duodenum to less than half of this size in the terminal ileum. In previous work, various villus enlarging and reducing factors present in the intestinal chyme were found to control villus size. A villus enlarging factor which appeared to reach the intestine through the duodenal papilla was presently investigated.
Transplants of duodenal papilla, together with a small segment of the duodenum, were made to isolated ileal segments and to the lower ileum. At both sites, the transplants elicited a marked villus enlargement within a month. A previous finding was that villus size decreased in isolated duodenal segments unless the duodenal papilla was present.
In the next experiments, the bile‐drainage was diverted from the duodenal papilla by implanting the bile duct into an isolated ileal segment which in turn was joined to the colon. The duodenal papilla which now transmitted only pancreatic secretions was then transplanted to the ileum. The bile caused only moderate villus enlargement in the ileal segments whereas marked villus enlargement took place in the ileum receiving the pancreatic secretions.
It was concluded that a villus enlarging influence reached the intestine through the duodenal papilla. The pancreatic secretions appeared to play a major role in this influence. |
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ISSN: | 0002-9106 1553-0795 |
DOI: | 10.1002/aja.1001320204 |