Steroidogenesis inhibitors. 1. Adrenal inhibitory and interceptive activity of trilostane and related compounds

Several methylated derivatives of trilostane were prepared. Methylation of C-4 or C-4 and C-17 changes this relatively selective adrenal inhibitor to compounds with increased ovarian/placental inhibitory activity with decreased adrenal inhibitory activity.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1984-07, Vol.27 (7), p.928-931
Hauptverfasser:	Christiansen, Rokbert G, Neumann, Helmut C, Salvador, U. Joseph, Bell, Malcolm R, Schane, H. Philip, Creange, John E, Potts, Gordon O, Anzalone, A. J
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors Abortifacient Agents - pharmacology Abortifacient Agents, Steroidal - pharmacology Adrenal Glands - drug effects Adrenocorticotropic Hormone - pharmacology Animals Corticosterone - blood Dihydrotestosterone - analogs & derivatives Dihydrotestosterone - pharmacology Female Macaca mulatta Magnetic Resonance Spectroscopy Pregnancy Progesterone - blood Pseudopregnancy - blood Rats Spectrophotometry, Infrared
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Beschreibung
Zusammenfassung:	Several methylated derivatives of trilostane were prepared. Methylation of C-4 or C-4 and C-17 changes this relatively selective adrenal inhibitor to compounds with increased ovarian/placental inhibitory activity with decreased adrenal inhibitory activity.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00373a021