Evidence for disordered control of 1,25-dihydroxyvitamin D production in absorptive hypercalciuria

THE frequency with which an increase in the circulating concentration of 1,25-dihydroxyvitamin D (1,25-(OH) 2 D) has been observed in patients with idiopathic or absorptive hypercalciuria is a matter of controversy. 1 2 3 4 5 6 7 Although it is possible that the differing experiences reported by various investigators may reflect true demographic differences in the patient populations studied, a careful reading of the literature suggests that this disagreement may be based in large part on the diagnostic criteria and conditions of study peculiar to individual investigators. Using rather stringent criteria for patient selection, we observed an increase in the plasma concentration of 1,25-(OH) 2 D . . .