Evaluation of the effectiveness of 2H-1, 3-Oxazine-2,6(3H)-dione (Oxauracil) in the treatment of herpes simplex virus (HSV)-Induced acute encephalitis in mice

Treatment of suckling mice with the pyrimidine analogue 2H‐1,3‐oxazine‐2,6(3H)‐dione (oxauracil) proved successful in reducing mortality associated with HSV‐2‐induced encephalitis. Oxauracil did not decrease mortality associated with HSV‐1 infection; however, there was an increased survival time and...

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Veröffentlicht in:	Journal of medical virology 1984, Vol.13 (4), p.371-375
Hauptverfasser:	Seal, Lawton A., Jamison, Richard M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - therapeutic use Biological and medical sciences Brain - microbiology Drug Evaluation encephalitis Encephalitis - drug therapy Encephalitis - microbiology Herpes Simplex - drug therapy Herpes Simplex - microbiology herpes simplex virus herpes simplex virus 2 Medical sciences Mice oxauracil Oxazines Pharmacology. Drug treatments Simplexvirus - isolation & purification Uracil - analogs & derivatives Uracil - therapeutic use
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Beschreibung
Zusammenfassung:	Treatment of suckling mice with the pyrimidine analogue 2H‐1,3‐oxazine‐2,6(3H)‐dione (oxauracil) proved successful in reducing mortality associated with HSV‐2‐induced encephalitis. Oxauracil did not decrease mortality associated with HSV‐1 infection; however, there was an increased survival time and a decrease in the amount of infectious virus recovered from the brains of HSV‐1‐infected animals.
ISSN:	0146-6615 1096-9071
DOI:	10.1002/jmv.1890130408