On the functional significance of the circuit of papez

This study was performed with the aim of clarifying the functional properties of the circuit of Papez as a feedback loop regulating hippocampal activity. The circulation in the loop of volleys of impulses elicited by delivering to the hippocampus trains of low-frequency electrical stimuli was studie...

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Veröffentlicht in:Brain research 1971-07, Vol.30 (2), p.357-374
Hauptverfasser: Parmeggiani, P.L., Azzaroni, A., Lenzi, P.
Format: Artikel
Sprache:eng
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Zusammenfassung:This study was performed with the aim of clarifying the functional properties of the circuit of Papez as a feedback loop regulating hippocampal activity. The circulation in the loop of volleys of impulses elicited by delivering to the hippocampus trains of low-frequency electrical stimuli was studied in the cat by recording unit activity at mammillary, thalamic, cingulate and hippocampal levels. The results show the properties of two feedback loops, one related to the nucleus anterior ventralis and the other to the nucleus anterior medialis. The output of the nucleus anterior ventralis is dependent on the hippocampal output, whereas the output of the nucleus anterior medialis is affected by both hippocampal and extralimbic thalamo-neocortical influences. The intermodulation of septal and feedback volleys at the level of the hippocampal region appears, in physiological conditions, to underlie the regulation of hippocampal bioelectrical activity in general and of theta rhythm in particular. A revelant effect of the output of the anterior thalamic nuclei consists in the depression of unit activity of the gyrus cinguli and area retrosplenialis.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(71)90086-2