Identification of a plasma metabolite of 5-(2-bromo-E-ethenyl)-2′-deoxyuridine

A prominent plasma metabolite was detected in animals and man after oral administration of 5‐(2‐bromo‐E‐ethenyl)‐2′‐deoxyuridine. The metabolite was isolated by solvent extraction and high‐performance liquid chromatography and was identified by mass spectrometry as 5‐(2‐bromo‐E‐ethenyl)uracil....

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Veröffentlicht in:	Biological Mass Spectrometry 1984-04, Vol.11 (4), p.199-201
Hauptverfasser:	Robinson, Yvonne, Gerry, Norma, Brownsill, Robin D., Vose, Colin W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Analysis Animals Antiviral Agents - administration & dosage Biological and medical sciences Deoxyuridine - administration & dosage Deoxyuridine - analogs & derivatives Dogs General pharmacology Herpesviridae - drug effects Humans Macaca mulatta Mass Spectrometry Medical sciences Pharmacology. Drug treatments Rabbits Rats
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Beschreibung
Zusammenfassung:	A prominent plasma metabolite was detected in animals and man after oral administration of 5‐(2‐bromo‐E‐ethenyl)‐2′‐deoxyuridine. The metabolite was isolated by solvent extraction and high‐performance liquid chromatography and was identified by mass spectrometry as 5‐(2‐bromo‐E‐ethenyl)uracil.
ISSN:	0306-042X 1096-9888
DOI:	10.1002/bms.1200110412