Chromosomal localization of the mouse homolog of the Huntington's disease linked G8 (D4S10) marker

The human DNA probe G8 defines D4S10, a polymorphic locus tightly linked to the Huntington's disease gene on human chromosome 4. A subclone of G8, pSC33, showed significant cross-hybridization to discrete restriction fragments in total genomic mouse DNA. The probe detected restriction fragment...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	DNA (New York, N.Y.) N.Y.), 1987-10, Vol.6 (5), p.401-407
Hauptverfasser:	Cheng, S V, Gross Lugo, T, Tanzi, R E, Whitney, 3rd, J B, Fournier, R E, Gusella, J F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromosome Mapping Huntington Disease - genetics Mice Mice, Inbred Strains Nucleic Acid Hybridization Polymorphism, Restriction Fragment Length Sequence Homology, Nucleic Acid
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The human DNA probe G8 defines D4S10, a polymorphic locus tightly linked to the Huntington's disease gene on human chromosome 4. A subclone of G8, pSC33, showed significant cross-hybridization to discrete restriction fragments in total genomic mouse DNA. The probe detected restriction fragment length polymorphisms (RFLPs) with the enzymes Taq I and Msp I, permitting chromosomal localization of the mouse G8 homolog by linkage analysis using three sets of recombinant inbred mouse strains: BXH, BXD, and AKXD. The mouse locus was mapped to the central region of chromosome 11 at 1 centiMorgan from the SPARC gene, a locus whose human counterpart is on human chromosome 5.
ISSN:	0198-0238
DOI:	10.1089/dna.1987.6.401