Vasopressin increases 45Ca2+ influx in rat aortic smooth muscle cells

[Arg8]Vasopressin (AVP)-induced 45Ca2+ influx was examined in vascular smooth muscle cells derived from rat aorta. AVP stimulated the 45Ca2+ influx in a concentration-dependent manner. The effect was abolished in the presence of La3+. The dihydropyridine calcium channel antagonist darodipine did not...

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Veröffentlicht in:	Biochemical and biophysical research communications 1987-10, Vol.148 (1), p.273-278
Hauptverfasser:	Wallnöfer, A, Cauvin, C, Rüegg, U T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - drug effects Aorta - metabolism Arginine Vasopressin - pharmacology Calcium - metabolism Calcium Channel Blockers - pharmacology Cells, Cultured Kinetics Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Rats Rats, Inbred WKY
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Zusammenfassung:	[Arg8]Vasopressin (AVP)-induced 45Ca2+ influx was examined in vascular smooth muscle cells derived from rat aorta. AVP stimulated the 45Ca2+ influx in a concentration-dependent manner. The effect was abolished in the presence of La3+. The dihydropyridine calcium channel antagonist darodipine did not affect the AVP-induced influx of 45Ca2+. These data suggest that AVP stimulates in these cultured aortic smooth muscle cells a receptor-operated channel (ROC) that is permeable to Ca2+.
ISSN:	0006-291X
DOI:	10.1016/0006-291X(87)91106-5