Cotrimoxazole Prophylaxis in Patients With Leukemia and Prolonged Granulocytopenia

Sixty-three patients with acute nonlymphoid leukemia (ANLL) under cytostatic treatment were investigated in a randomized trial to determine whether oral administration of cotrimoxazole (TMP/STX) would reduce the rate of infection. Four significant differences were observed between the group given TM...

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Veröffentlicht in:	The American journal of the medical sciences 1984-05, Vol.287 (3), p.7-9
Hauptverfasser:	Martino, Piero, Venditti, Mario, Petti, Maria Concetta, Mandelli, Franco, Serra, Pietro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Administration, Oral Adult Agranulocytosis - complications Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial Infections - prevention & control Biological and medical sciences Clinical Trials as Topic Cotrimoxazole prophylaxis Drug Combinations - administration & dosage Female Granulocytopenia Humans Leukemia Leukemia - complications Male Medical sciences Pharmacology. Drug treatments Random Allocation Sulfamethoxazole - administration & dosage Trimethoprim - administration & dosage Trimethoprim, Sulfamethoxazole Drug Combination
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Zusammenfassung:	Sixty-three patients with acute nonlymphoid leukemia (ANLL) under cytostatic treatment were investigated in a randomized trial to determine whether oral administration of cotrimoxazole (TMP/STX) would reduce the rate of infection. Four significant differences were observed between the group given TMP/STX (30 patients) and the control group (33 patients): 1) the mean duration of severe granulocytopenia (≤500PMN/mm3) before the first febrile episode was longer in prophylaxis group, 14.26 days versus four in the control group (p
ISSN:	0002-9629 1538-2990
DOI:	10.1097/00000441-198405000-00002