The Influence of Prazosin and Propranolol on Serum Lipids and Atherosclerosis in Standard Fed Pigs

: The influence of prazosin and propranolol on serum lipids and atherosclerosis was evaluated in standard fed pigs during a nine months experimental period. The incidence and severity of atherosclerotic lesions was very low, and no difference could be observed neither between the two drugs nor betwe...

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Veröffentlicht in:	Acta pharmacologica et toxicologica 1984-04, Vol.54 (4), p.270-272
Hauptverfasser:	Helgeland, Anders, Eriksen, Karin, Foss, Per Olav, Nafstad, Inger, Solberg, Lars Aage, Tollersrud, Svcrre
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - pathology Arteriosclerosis - blood Arteriosclerosis - etiology Arteriosclerosis - pathology Atherosclerosis Biological and medical sciences Cholesterol - blood Cholesterol, HDL Coronary Vessels - pathology Dietary Fats - administration & dosage Female General and cellular metabolism. Vitamins Lipids - blood Lipoproteins, HDL - blood Male Medical sciences Pharmacology. Drug treatments pigs prazosin Prazosin - pharmacology propranolol Propranolol - pharmacology Quinazolines - pharmacology serum lipids Swine
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Zusammenfassung:	: The influence of prazosin and propranolol on serum lipids and atherosclerosis was evaluated in standard fed pigs during a nine months experimental period. The incidence and severity of atherosclerotic lesions was very low, and no difference could be observed neither between the two drugs nor between the drug groups and the placebo group. Prazosin and propranolol induced no marked change in the serum lipid profile. The results could be explained by the very low fat content, 3.6 per cent, in the present standard diet.
ISSN:	0001-6683 1600-0773
DOI:	10.1111/j.1600-0773.1984.tb01929.x