Effect of phytic acid on colonic epithelial cell proliferation
Cell proliferation was studied in descending, transverse and ascending colonic crypts of rats fed either 0%, 0.6%, 1.2% or 2.0% phytic acid (PA). Significant effects of phytic acid were seen only in the descending colon. No changes in crypt height were observed. Both the 1.2 and 2.0% phytic acid gro...
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| Veröffentlicht in: | Cancer letters 1987-11, Vol.37 (3), p.317-325 |
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| container_title | Cancer letters |
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| creator | Nielsen, B.K. Thompson, L.U. Bird, R.P. |
| description | Cell proliferation was studied in descending, transverse and ascending colonic crypts of rats fed either 0%, 0.6%, 1.2% or 2.0% phytic acid (PA). Significant effects of phytic acid were seen only in the descending colon. No changes in crypt height were observed. Both the 1.2 and 2.0% phytic acid groups exhibited significantly lower uppermost labelled cells than the control group. Animals given 1.2% and 2.0% phytic acid also showed significantly reduced DNA synthetic cells, as indicated by lower labelling indices. |
| doi_str_mv | 10.1016/0304-3835(87)90117-0 |
| format | Article |
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Significant effects of phytic acid were seen only in the descending colon. No changes in crypt height were observed. Both the 1.2 and 2.0% phytic acid groups exhibited significantly lower uppermost labelled cells than the control group. Animals given 1.2% and 2.0% phytic acid also showed significantly reduced DNA synthetic cells, as indicated by lower labelling indices.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/0304-3835(87)90117-0</identifier><identifier>PMID: 3677063</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Antineoplastic agents ; Biological and medical sciences ; Body Weight - drug effects ; Cell Cycle - drug effects ; Colon - cytology ; DNA - biosynthesis ; Epithelial Cells ; General aspects ; Intestinal Mucosa - cytology ; Male ; Medical sciences ; Pharmacology. 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Significant effects of phytic acid were seen only in the descending colon. No changes in crypt height were observed. Both the 1.2 and 2.0% phytic acid groups exhibited significantly lower uppermost labelled cells than the control group. Animals given 1.2% and 2.0% phytic acid also showed significantly reduced DNA synthetic cells, as indicated by lower labelling indices.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Cell Cycle - drug effects</subject><subject>Colon - cytology</subject><subject>DNA - biosynthesis</subject><subject>Epithelial Cells</subject><subject>General aspects</subject><subject>Intestinal Mucosa - cytology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. 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| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 1987-11, Vol.37 (3), p.317-325 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Antineoplastic agents Biological and medical sciences Body Weight - drug effects Cell Cycle - drug effects Colon - cytology DNA - biosynthesis Epithelial Cells General aspects Intestinal Mucosa - cytology Male Medical sciences Pharmacology. Drug treatments Phytic Acid - pharmacology Rats |
| title | Effect of phytic acid on colonic epithelial cell proliferation |
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