Effect of phytic acid on colonic epithelial cell proliferation

Effect of phytic acid on colonic epithelial cell proliferation

Cell proliferation was studied in descending, transverse and ascending colonic crypts of rats fed either 0%, 0.6%, 1.2% or 2.0% phytic acid (PA). Significant effects of phytic acid were seen only in the descending colon. No changes in crypt height were observed. Both the 1.2 and 2.0% phytic acid gro...

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Veröffentlicht in:Cancer letters 1987-11, Vol.37 (3), p.317-325
Hauptverfasser: Nielsen, B.K., Thompson, L.U., Bird, R.P.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antineoplastic agents
Biological and medical sciences
Body Weight - drug effects
Cell Cycle - drug effects
Colon - cytology
DNA - biosynthesis
Epithelial Cells
General aspects
Intestinal Mucosa - cytology
Male
Medical sciences
Pharmacology. Drug treatments
Phytic Acid - pharmacology
Rats
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Zusammenfassung:Cell proliferation was studied in descending, transverse and ascending colonic crypts of rats fed either 0%, 0.6%, 1.2% or 2.0% phytic acid (PA). Significant effects of phytic acid were seen only in the descending colon. No changes in crypt height were observed. Both the 1.2 and 2.0% phytic acid groups exhibited significantly lower uppermost labelled cells than the control group. Animals given 1.2% and 2.0% phytic acid also showed significantly reduced DNA synthetic cells, as indicated by lower labelling indices.
ISSN:0304-3835
1872-7980
DOI:10.1016/0304-3835(87)90117-0