Influence of gender on the disposition of cefotaxime and desacetylcefotaxime

The pharmacokinetics of cefotaxime and desacetylcefotaxime were evaluated in 11 female and 13 male subjects with end-stage renal disease. Subjects received single 1- or 2-g intravenous doses of cefotaxime sodium. Serum, urine, and dialysate concentrations of cefotaxime and desacetylcefotaxime were d...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Therapeutic drug monitoring 1987-09, Vol.9 (3), p.259-262
Hauptverfasser:	GUAY, D. R. P, MATZKE, G. R, HEIM, K. L, HALSTENSON, C. E, ABRAHAM, P. A, KEANE, W. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cefotaxime - analogs & derivatives Cefotaxime - pharmacokinetics Female Humans Kidney Failure, Chronic - metabolism Male Medical sciences Pharmacology. Drug treatments Sex Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The pharmacokinetics of cefotaxime and desacetylcefotaxime were evaluated in 11 female and 13 male subjects with end-stage renal disease. Subjects received single 1- or 2-g intravenous doses of cefotaxime sodium. Serum, urine, and dialysate concentrations of cefotaxime and desacetylcefotaxime were determined using high performance liquid chromatography. The results indicate that gender has no clinically significant influence on the disposition of cefotaxime or its active metabolite desacetylcefotaxime.
ISSN:	0163-4356 1536-3694
DOI:	10.1097/00007691-198709000-00002