Aromatase activity in uterine leiomyomata

Of the 24 samples of leiomyoma tissues examined 14 were shown to have aromatase activity in vitro. In contrast only 1 of 12 samples of myometrium had any demonstrable activity. Measurements of tissue oestrogen levels showed no correlation with the amount of aromatase activity although oestradiol lev...

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Veröffentlicht in:	Journal of steroid biochemistry 1984-05, Vol.20 (5), p.1195-1200
Hauptverfasser:	Folkerd, E.J., Newton, C.J., Davidson, K., Anderson, M.C., James, V.H.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstenedione - metabolism Aromatase - metabolism Biological and medical sciences Estradiol - metabolism Estrone - analogs & derivatives Estrone - metabolism Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Leiomyoma - enzymology Medical sciences Microbial Collagenase - metabolism Myometrium - enzymology Oxidoreductases - metabolism Tumors Uterine Neoplasms - enzymology
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Beschreibung
Zusammenfassung:	Of the 24 samples of leiomyoma tissues examined 14 were shown to have aromatase activity in vitro. In contrast only 1 of 12 samples of myometrium had any demonstrable activity. Measurements of tissue oestrogen levels showed no correlation with the amount of aromatase activity although oestradiol levels were consistently higher in the tumour tissues compared with the normal myometrium.
ISSN:	0022-4731
DOI:	10.1016/0022-4731(84)90366-2