Fibroblast stimulation in schistosomiasis. V. Egg granuloma macrophages spontaneously secrete a fibroblast-stimulating factor

Schistosoma mansoni, egg granuloma macrophages are activated in vivo to secrete fibrogenic molecules functionally distinct from interleukin I which might contribute to pathogenesis of hepatic fibrosis in schistosomiasis

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Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 1984-06, Vol.132 (6), p.3142-3148
Hauptverfasser:	Wyler, D.J, Stadecker, M.J, Dinarello, C.A, O'Dea, J.F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Separation Female fibroblasts Fibroblasts - cytology Fibroblasts - metabolism granuloma Granuloma - immunology Granuloma - pathology Humans immunopathology Interleukin-1 - physiology liver macrophages Macrophages - immunology Macrophages - metabolism Mice Mice, Inbred C57BL Monokines Ovum - metabolism Pathology, Trematoda Protein Biosynthesis Proteins - physiology Schistosoma mansoni Schistosoma mansoni - metabolism Schistosomiasis - immunology Schistosomiasis - pathology Thymidine - metabolism
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Beschreibung
Zusammenfassung:	Schistosoma mansoni, egg granuloma macrophages are activated in vivo to secrete fibrogenic molecules functionally distinct from interleukin I which might contribute to pathogenesis of hepatic fibrosis in schistosomiasis
ISSN:	0022-1767 1550-6606
DOI:	10.4049/jimmunol.132.6.3142