Dissociation of the cardiovascular and prolactin-releasing activities of norvaline2-TRH

The effects of thyrotropin-releasing hormone (TRH) and norvaline2-TRH (Nva2-TRH) on blood pressure, heart rate and plasma prolactin levels in conscious rats have been compared. Systemic injection of TRH or Nva2-TRH (1 mg/kg or 5 mg/kg) produced equipotent increases in plasma prolactin. On the other...

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Veröffentlicht in:	Neuropeptides (Edinburgh) 1987-07, Vol.10 (1), p.29-36
Hauptverfasser:	LABROO, V. M, COHEN, L. A, LOZOVSKY, D, SIREN, A.-L, FEUERSTEIN, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Pressure - drug effects Cardiovascular System - drug effects Fundamental and applied biological sciences. Psychology Heart Rate - drug effects Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis Male Prolactin - blood Rats Rats, Inbred Strains Thyrotropin-Releasing Hormone - analogs & derivatives Thyrotropin-Releasing Hormone - pharmacology Vertebrates: endocrinology
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Zusammenfassung:	The effects of thyrotropin-releasing hormone (TRH) and norvaline2-TRH (Nva2-TRH) on blood pressure, heart rate and plasma prolactin levels in conscious rats have been compared. Systemic injection of TRH or Nva2-TRH (1 mg/kg or 5 mg/kg) produced equipotent increases in plasma prolactin. On the other hand, while TRH significantly increases blood pressure and heart rate, Nva2-TRH was essentially inactive. Thus, two contrasting analogues are now available: 4-NO2-Im-TRH (Neuropeptides, 8, 63, 1986) has full cardiovascular activity and no PRL-releasing activity, while Nva2-TRH has no cardiovascular activity and full PRL-releasing activity of TRH.
ISSN:	0143-4179 1532-2785
DOI:	10.1016/0143-4179(87)90086-2