Synthesis and antimalarial and antitumor effects of 2-amino-4-(hydrazino and hydroxyamino)-6-[(aryl)thio]quinazolines

A variety of analogues of 2,4-diamino-6-[(aryl)thio]quinazolines with known antimalarial properties were prepared wherein the 4-amino group was replaced by hydrazino and hydroxyamino moieties. Such changes were found to reduce markedly the antimalarial and antitumor properties of this series.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1987-11, Vol.30 (11), p.2151-2154
Hauptverfasser:	Werbel, L M, Degnan, M J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials - chemical synthesis Antimalarials - pharmacology Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Hydrazines - chemical synthesis Hydrazines - pharmacology Hydroxylamines - chemical synthesis Hydroxylamines - pharmacology Mice Quinazolines - chemical synthesis Quinazolines - pharmacology Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A variety of analogues of 2,4-diamino-6-[(aryl)thio]quinazolines with known antimalarial properties were prepared wherein the 4-amino group was replaced by hydrazino and hydroxyamino moieties. Such changes were found to reduce markedly the antimalarial and antitumor properties of this series.
ISSN:	0022-2623
DOI:	10.1021/jm00394a038