The relationship between tumor response and survival following radiotherapy for carcinoma of the bronchus

Tumor response was closely observed in a randomized controlled trial of a radiosensitizing drug in the radiotherapy of carcinoma of the bronchus. The persistence of tumor cells in the sputum after treatment and the degree of regression measured radiologically at two months did not correlate with the...

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Veröffentlicht in:	Int. J. Radiat. Oncol., Biol. Phys.; (United States) Biol. Phys.; (United States), 1984-04, Vol.10 (4), p.503-508
Hauptverfasser:	Saunders, M.I., Barltrop, M.A., Rassa, P.M., Anderson, P.J., Dische, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	550603 - Medicine- External Radiation in Therapy- (1980-) ANTINEOPLASTIC DRUGS AZOLES Biological and medical sciences BIOLOGICAL MATERIALS BIOLOGY BODY FLUIDS BRONCHI Bronchial carcinoma Bronchial Neoplasms - mortality Bronchial Neoplasms - pathology Bronchial Neoplasms - radiotherapy Carcinoma - mortality Carcinoma - radiotherapy Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - radiotherapy CARCINOMAS CYTOLOGY DIAGNOSTIC TECHNIQUES DISEASES DRUGS EVALUATION HETEROCYCLIC COMPOUNDS Humans IMIDAZOLES MATERIALS Medical sciences MEDICINE MISONIDAZOLE NEOPLASMS NUCLEAR MEDICINE ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS Pneumology Prognosis Radiological assessment RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE RADIOSENSITIZERS RADIOTHERAPY Random Allocation RESPIRATORY SYSTEM SALIVA Sputum - cytology Survival THERAPY Time Factors TOMOGRAPHY Tumor response Tumors of the respiratory system and mediastinum
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Zusammenfassung:	Tumor response was closely observed in a randomized controlled trial of a radiosensitizing drug in the radiotherapy of carcinoma of the bronchus. The persistence of tumor cells in the sputum after treatment and the degree of regression measured radiologically at two months did not correlate with the subsequent course. However, total regression of tumor and time to regrowth both assessed radiologically showed a highly significant correlation with highly ( P < 0.0005).
ISSN:	0360-3016 1879-355X
DOI:	10.1016/0360-3016(84)90030-0