A non-cholinergic function for acetylcholinesterase in the substantia nigra: behavioural evidence
Acetylcholinesterase is released from substantia nigra neurons, independently of cholinergic transmission. In an attempt to discover the functional significance of this phenomenon, the behavioural effects of injecting acetylcholinesterase into one substantia nigra of the rat were investigated. Follo...
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| Veröffentlicht in: | Experimental brain research 1984-01, Vol.54 (3), p.513-520 |
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| container_title | Experimental brain research |
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| creator | Greenfield, S A Chubb, I W Grünewald, R A Henderson, Z May, J Portnoy, S Weston, J Wright, M C |
| description | Acetylcholinesterase is released from substantia nigra neurons, independently of cholinergic transmission. In an attempt to discover the functional significance of this phenomenon, the behavioural effects of injecting acetylcholinesterase into one substantia nigra of the rat were investigated. Following a single injection of the enzyme, intraperitoneal amphetamine evoked circling behaviour in a direction away from the side of injection. Purified acetylcholinesterase with a similar electrophoretic mobility to the endogenous secreted form, was far more potent in eliciting circling than much higher activities of commercial enzyme, consisting of several molecular species of acetylcholinesterase. Similar infusions of butyrylcholinesterase did not induce circling. Depending upon the amount of enzyme initially given, the behavioural effects of a single injection of acetylcholinesterase persisted for up to thirty days. During this period apomorphine, administered systemically, induced transient circling towards the acetylcholinesterase-treated side. It is concluded that secreted acetylcholinesterase has a functional significance within the substantia nigra, independent of cholinergic transmission. This released enzyme could exert long-term changes in the activity of the nigrostriatal system, involving modification of dopamine striatal receptors. |
| doi_str_mv | 10.1007/BF00235476 |
| format | Article |
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In an attempt to discover the functional significance of this phenomenon, the behavioural effects of injecting acetylcholinesterase into one substantia nigra of the rat were investigated. Following a single injection of the enzyme, intraperitoneal amphetamine evoked circling behaviour in a direction away from the side of injection. Purified acetylcholinesterase with a similar electrophoretic mobility to the endogenous secreted form, was far more potent in eliciting circling than much higher activities of commercial enzyme, consisting of several molecular species of acetylcholinesterase. Similar infusions of butyrylcholinesterase did not induce circling. Depending upon the amount of enzyme initially given, the behavioural effects of a single injection of acetylcholinesterase persisted for up to thirty days. During this period apomorphine, administered systemically, induced transient circling towards the acetylcholinesterase-treated side. It is concluded that secreted acetylcholinesterase has a functional significance within the substantia nigra, independent of cholinergic transmission. This released enzyme could exert long-term changes in the activity of the nigrostriatal system, involving modification of dopamine striatal receptors.</description><identifier>ISSN: 0014-4819</identifier><identifier>EISSN: 1432-1106</identifier><identifier>DOI: 10.1007/BF00235476</identifier><identifier>PMID: 6202543</identifier><language>eng</language><publisher>Germany</publisher><subject>Acetylcholine - metabolism ; Acetylcholinesterase - pharmacology ; Acetylcholinesterase - physiology ; Animals ; Apomorphine - pharmacology ; Behavior, Animal - drug effects ; Dopamine - metabolism ; Male ; Rats ; Receptors, Dopamine - drug effects ; Substance P - metabolism ; Substantia Nigra - physiology</subject><ispartof>Experimental brain research, 1984-01, Vol.54 (3), p.513-520</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c313t-3aaad1b200d52ec0858e0b9c04b48ad836de2403858768a2b42df50016ea4ed13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6202543$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Greenfield, S A</creatorcontrib><creatorcontrib>Chubb, I W</creatorcontrib><creatorcontrib>Grünewald, R A</creatorcontrib><creatorcontrib>Henderson, Z</creatorcontrib><creatorcontrib>May, J</creatorcontrib><creatorcontrib>Portnoy, S</creatorcontrib><creatorcontrib>Weston, J</creatorcontrib><creatorcontrib>Wright, M C</creatorcontrib><title>A non-cholinergic function for acetylcholinesterase in the substantia nigra: behavioural evidence</title><title>Experimental brain research</title><addtitle>Exp Brain Res</addtitle><description>Acetylcholinesterase is released from substantia nigra neurons, independently of cholinergic transmission. In an attempt to discover the functional significance of this phenomenon, the behavioural effects of injecting acetylcholinesterase into one substantia nigra of the rat were investigated. Following a single injection of the enzyme, intraperitoneal amphetamine evoked circling behaviour in a direction away from the side of injection. Purified acetylcholinesterase with a similar electrophoretic mobility to the endogenous secreted form, was far more potent in eliciting circling than much higher activities of commercial enzyme, consisting of several molecular species of acetylcholinesterase. Similar infusions of butyrylcholinesterase did not induce circling. Depending upon the amount of enzyme initially given, the behavioural effects of a single injection of acetylcholinesterase persisted for up to thirty days. During this period apomorphine, administered systemically, induced transient circling towards the acetylcholinesterase-treated side. It is concluded that secreted acetylcholinesterase has a functional significance within the substantia nigra, independent of cholinergic transmission. This released enzyme could exert long-term changes in the activity of the nigrostriatal system, involving modification of dopamine striatal receptors.</description><subject>Acetylcholine - metabolism</subject><subject>Acetylcholinesterase - pharmacology</subject><subject>Acetylcholinesterase - physiology</subject><subject>Animals</subject><subject>Apomorphine - pharmacology</subject><subject>Behavior, Animal - drug effects</subject><subject>Dopamine - metabolism</subject><subject>Male</subject><subject>Rats</subject><subject>Receptors, Dopamine - drug effects</subject><subject>Substance P - metabolism</subject><subject>Substantia Nigra - physiology</subject><issn>0014-4819</issn><issn>1432-1106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQhhdRaq1evAt78iBEZz-SbL3V4hcUvOg5TDaTdiXd1N2k4L83pUWPnoaZeXiZeRi7FHArAPK7hycAqVKdZ0dsLLSSiRCQHbMxgNCJNmJ6ys5i_Ny1KocRG2USZKrVmOGM-9YndtU2zlNYOsvr3tvOtZ7XbeBoqftuDuvYUcBI3HnerYjHvowd-s4h924Z8J6XtMKta_uADaetq8hbOmcnNTaRLg51wj6eHt_nL8ni7fl1PlskVgnVJQoRK1FKgCqVZMGkhqCcWtClNlgZlVUkNahhnmcGZallVafDRxmhpkqoCbve525C-9UPtxZrFy01DXpq-1gYAbmGaf4vKJQx01RmA3izB21oYwxUF5vg1hi-CwHFTnzxJ36Arw6pfbmm6hc9mFY_Dv59-A</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>Greenfield, S A</creator><creator>Chubb, I W</creator><creator>Grünewald, R A</creator><creator>Henderson, Z</creator><creator>May, J</creator><creator>Portnoy, S</creator><creator>Weston, J</creator><creator>Wright, M C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19840101</creationdate><title>A non-cholinergic function for acetylcholinesterase in the substantia nigra: behavioural evidence</title><author>Greenfield, S A ; Chubb, I W ; Grünewald, R A ; Henderson, Z ; May, J ; Portnoy, S ; Weston, J ; Wright, M C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-3aaad1b200d52ec0858e0b9c04b48ad836de2403858768a2b42df50016ea4ed13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Acetylcholine - metabolism</topic><topic>Acetylcholinesterase - pharmacology</topic><topic>Acetylcholinesterase - physiology</topic><topic>Animals</topic><topic>Apomorphine - pharmacology</topic><topic>Behavior, Animal - drug effects</topic><topic>Dopamine - metabolism</topic><topic>Male</topic><topic>Rats</topic><topic>Receptors, Dopamine - drug effects</topic><topic>Substance P - metabolism</topic><topic>Substantia Nigra - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Greenfield, S A</creatorcontrib><creatorcontrib>Chubb, I W</creatorcontrib><creatorcontrib>Grünewald, R A</creatorcontrib><creatorcontrib>Henderson, Z</creatorcontrib><creatorcontrib>May, J</creatorcontrib><creatorcontrib>Portnoy, S</creatorcontrib><creatorcontrib>Weston, J</creatorcontrib><creatorcontrib>Wright, M C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Greenfield, S A</au><au>Chubb, I W</au><au>Grünewald, R A</au><au>Henderson, Z</au><au>May, J</au><au>Portnoy, S</au><au>Weston, J</au><au>Wright, M C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A non-cholinergic function for acetylcholinesterase in the substantia nigra: behavioural evidence</atitle><jtitle>Experimental brain research</jtitle><addtitle>Exp Brain Res</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>54</volume><issue>3</issue><spage>513</spage><epage>520</epage><pages>513-520</pages><issn>0014-4819</issn><eissn>1432-1106</eissn><abstract>Acetylcholinesterase is released from substantia nigra neurons, independently of cholinergic transmission. In an attempt to discover the functional significance of this phenomenon, the behavioural effects of injecting acetylcholinesterase into one substantia nigra of the rat were investigated. Following a single injection of the enzyme, intraperitoneal amphetamine evoked circling behaviour in a direction away from the side of injection. Purified acetylcholinesterase with a similar electrophoretic mobility to the endogenous secreted form, was far more potent in eliciting circling than much higher activities of commercial enzyme, consisting of several molecular species of acetylcholinesterase. Similar infusions of butyrylcholinesterase did not induce circling. Depending upon the amount of enzyme initially given, the behavioural effects of a single injection of acetylcholinesterase persisted for up to thirty days. During this period apomorphine, administered systemically, induced transient circling towards the acetylcholinesterase-treated side. It is concluded that secreted acetylcholinesterase has a functional significance within the substantia nigra, independent of cholinergic transmission. This released enzyme could exert long-term changes in the activity of the nigrostriatal system, involving modification of dopamine striatal receptors.</abstract><cop>Germany</cop><pmid>6202543</pmid><doi>10.1007/BF00235476</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-4819 |
| ispartof | Experimental brain research, 1984-01, Vol.54 (3), p.513-520 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Acetylcholine - metabolism Acetylcholinesterase - pharmacology Acetylcholinesterase - physiology Animals Apomorphine - pharmacology Behavior, Animal - drug effects Dopamine - metabolism Male Rats Receptors, Dopamine - drug effects Substance P - metabolism Substantia Nigra - physiology |
| title | A non-cholinergic function for acetylcholinesterase in the substantia nigra: behavioural evidence |
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