A genetic linkage map of the human genome

We report the construction of a linkage map of the human genome, based on the pattern of inheritance of 403 polymorphic loci, including 393 RFLPs, in a panel of DNAs from 21 three-generation families. By a combination of mathematical linkage analysis and physical localization of selected clones, it...

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Veröffentlicht in:	Cell 1987-10, Vol.51 (2), p.319-337
Hauptverfasser:	Donis-Keller, Helen, Green, Philip, Helms, Cynthia, Cartinhour, Samuel, Weiffenbach, Barbara, Stephens, Karen, Keith, Tim P., Bowden, Donald W., Smith, Douglas R., Lander, Eric S., Botstein, David, Akots, Gita, Rediker, Kenneth S., Gravius, Thomas, Brown, Valerie A., Rising, Marcia B., Parker, Carol, Powers, Jody A., Watt, Diane E., Kauffman, Erick R., Bricker, Angela, Phipps, Pamela, Muller-Kahle, Hans, Fulton, Thomas R., Ng, Siu, Schumm, James W., Braman, Jeffrey C., Knowlton, Robert G., Barker, David F., Crooks, Steven M., Lincoln, Steven E., Daly, Mark J., Abrahamson, Jeff
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromosome Mapping Fundamental and applied biological sciences. Psychology Genes Genes. Genome Genetic Linkage Humans Molecular and cellular biology Molecular genetics Pedigree Polymorphism, Genetic Recombination, Genetic Sex Characteristics
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Beschreibung
Zusammenfassung:	We report the construction of a linkage map of the human genome, based on the pattern of inheritance of 403 polymorphic loci, including 393 RFLPs, in a panel of DNAs from 21 three-generation families. By a combination of mathematical linkage analysis and physical localization of selected clones, it was possible to arrange these loci into linkage groups representing 23 human chromosomes. We estimate that the linkage map is detectably linked to at least 95% of the DNA in the human genome.
ISSN:	0092-8674 1097-4172
DOI:	10.1016/0092-8674(87)90158-9