Expression of a possible constitutional “hot spot” in sperm chromosomes of a patient treated for Wilms' tumor
Sperm chromosomes were studied in a man who was treated for Wilms' tumor with radiotherapy (RT) and chemotherapy (CT) 18 years ago. Human pronuclear sperm chromosomes were obtained after penetration of zona-free hamster eggs. Eighty-nine sperm chromosome complements were analyzed; 12.4% of them...
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| Veröffentlicht in: | Cancer Genet. Cytogenet.; (United States) 1987-11, Vol.29 (1), p.91-96 |
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| container_title | Cancer Genet. Cytogenet.; (United States) |
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| creator | Genescà, Anna Miró, Rosa Rosa Caballin, M. Benet, Jordi Navarro, Joaquima Templado, Cristina Bonfill, Xavier Egozcue, Josep |
| description | Sperm chromosomes were studied in a man who was treated for Wilms' tumor with radiotherapy (RT) and chemotherapy (CT) 18 years ago. Human pronuclear sperm chromosomes were obtained after penetration of zona-free hamster eggs. Eighty-nine sperm chromosome complements were analyzed; 12.4% of them showed structural anomalies. This percentage was statistically different from the one found in our laboratory for controls (
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| doi_str_mv | 10.1016/0165-4608(87)90034-3 |
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p<0.05). Five of eleven structurally abnormal metaphases had the same aberration: fission of chromosome #1 with the breakpoint at or near the centromere. Breaks and rearrangements of chromosome #1, often involving the centromere region, are among the most frequent anomalies found in Wilms' tumor cells.</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/0165-4608(87)90034-3</identifier><identifier>PMID: 2822226</identifier><identifier>CODEN: CGCYDF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>560151 - Radiation Effects on Animals- Man ; Adult ; Antineoplastic Agents - adverse effects ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; BIOLOGICAL RADIATION EFFECTS ; BODY ; CHEMOTHERAPY ; CHROMOSOMAL ABERRATIONS ; Chromosome Aberrations - drug effects ; Chromosome Aberrations - radiation effects ; Chromosome Banding ; CHROMOSOMES ; Chromosomes, Human, Pair 1 ; DELAYED RADIATION EFFECTS ; DISEASES ; GAMETES ; GENETIC EFFECTS ; Genetic Markers ; GENETIC RADIATION EFFECTS ; GERM CELLS ; Humans ; Karyotyping ; Kidney Neoplasms - drug therapy ; Kidney Neoplasms - radiotherapy ; Kidney Neoplasms - therapy ; KIDNEYS ; Male ; Medical sciences ; MEDICINE ; MUTATIONS ; NEOPLASMS ; Nephrology. Urinary tract diseases ; NUCLEAR MEDICINE ; ORGANS ; RADIATION EFFECTS ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIOINDUCTION ; RADIOLOGY ; RADIOTHERAPY ; SIDE EFFECTS ; SPERMATOZOA ; Spermatozoa - ultrastructure ; THERAPY ; Tumors of the urinary system ; Wilms Tumor - drug therapy ; Wilms Tumor - radiotherapy ; Wilms Tumor - therapy</subject><ispartof>Cancer Genet. Cytogenet.; (United States), 1987-11, Vol.29 (1), p.91-96</ispartof><rights>1987</rights><rights>1988 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-c52f2e076d57d3327ee41116556eb61f5d5a649b514a29d5044885dfd1bec6d33</citedby><cites>FETCH-LOGICAL-c444t-c52f2e076d57d3327ee41116556eb61f5d5a649b514a29d5044885dfd1bec6d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0165-4608(87)90034-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7422199$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2822226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5665464$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Genescà, Anna</creatorcontrib><creatorcontrib>Miró, Rosa</creatorcontrib><creatorcontrib>Rosa Caballin, M.</creatorcontrib><creatorcontrib>Benet, Jordi</creatorcontrib><creatorcontrib>Navarro, Joaquima</creatorcontrib><creatorcontrib>Templado, Cristina</creatorcontrib><creatorcontrib>Bonfill, Xavier</creatorcontrib><creatorcontrib>Egozcue, Josep</creatorcontrib><creatorcontrib>Universitat Autonoma de Barcelona, Spain</creatorcontrib><title>Expression of a possible constitutional “hot spot” in sperm chromosomes of a patient treated for Wilms' tumor</title><title>Cancer Genet. Cytogenet.; (United States)</title><addtitle>Cancer Genet Cytogenet</addtitle><description>Sperm chromosomes were studied in a man who was treated for Wilms' tumor with radiotherapy (RT) and chemotherapy (CT) 18 years ago. Human pronuclear sperm chromosomes were obtained after penetration of zona-free hamster eggs. Eighty-nine sperm chromosome complements were analyzed; 12.4% of them showed structural anomalies. This percentage was statistically different from the one found in our laboratory for controls (
p<0.05). Five of eleven structurally abnormal metaphases had the same aberration: fission of chromosome #1 with the breakpoint at or near the centromere. Breaks and rearrangements of chromosome #1, often involving the centromere region, are among the most frequent anomalies found in Wilms' tumor cells.</description><subject>560151 - Radiation Effects on Animals- Man</subject><subject>Adult</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>BODY</subject><subject>CHEMOTHERAPY</subject><subject>CHROMOSOMAL ABERRATIONS</subject><subject>Chromosome Aberrations - drug effects</subject><subject>Chromosome Aberrations - radiation effects</subject><subject>Chromosome Banding</subject><subject>CHROMOSOMES</subject><subject>Chromosomes, Human, Pair 1</subject><subject>DELAYED RADIATION EFFECTS</subject><subject>DISEASES</subject><subject>GAMETES</subject><subject>GENETIC EFFECTS</subject><subject>Genetic Markers</subject><subject>GENETIC RADIATION EFFECTS</subject><subject>GERM CELLS</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Kidney Neoplasms - drug therapy</subject><subject>Kidney Neoplasms - radiotherapy</subject><subject>Kidney Neoplasms - therapy</subject><subject>KIDNEYS</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MEDICINE</subject><subject>MUTATIONS</subject><subject>NEOPLASMS</subject><subject>Nephrology. 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MAT</subject><subject>RADIOINDUCTION</subject><subject>RADIOLOGY</subject><subject>RADIOTHERAPY</subject><subject>SIDE EFFECTS</subject><subject>SPERMATOZOA</subject><subject>Spermatozoa - ultrastructure</subject><subject>THERAPY</subject><subject>Tumors of the urinary system</subject><subject>Wilms Tumor - drug therapy</subject><subject>Wilms Tumor - radiotherapy</subject><subject>Wilms Tumor - therapy</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd2K1TAQx4Mo69nVN1AIIn5cVJM0H-2NIMv6AQveKF6GNJlyIm3TTdJF7_ZB3JfbJzH1lHOpgZAJ85th_vNH6Aklbyih8m25ouKSNK8a9bolpOZVfQ_taKPqinMh76PdEXmITlP6QQhRrJUn6IQ1rBy5Q1cXP-cIKfkw4dBjg-dQPt0A2IYpZZ-XXFJmwHc3v_ch4zSHfHdzi_1UQogjtvsYxpDCCGlrYLKHKeMcwWRwuA8Rf_fDmF7ivIwhPkIPejMkeLy9Z-jbh4uv55-qyy8fP5-_v6ws5zxXVrCeAVHSCeXqmikATmnRIyR0kvbCCSN52wnKDWudIJw3jXC9ox1YWSrO0LND31Bk6GR9BrsvoiawWQspBZe8QC8O0BzD1QIp69EnC8NgJghL0g0lUjDyf5AKQgRXK8gPoI1lkxF6PUc_mvhLU6JX3_Rqil5N0Y3Sf33T67RPt_5LN4I7Fm1GlfzzLW-SNUMfzWR9OmKKM0bbtmDvDhiUzV57iKtwmCw4H1fdLvh_z_EHSP61mQ</recordid><startdate>19871101</startdate><enddate>19871101</enddate><creator>Genescà, Anna</creator><creator>Miró, Rosa</creator><creator>Rosa Caballin, M.</creator><creator>Benet, Jordi</creator><creator>Navarro, Joaquima</creator><creator>Templado, Cristina</creator><creator>Bonfill, Xavier</creator><creator>Egozcue, Josep</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19871101</creationdate><title>Expression of a possible constitutional “hot spot” in sperm chromosomes of a patient treated for Wilms' tumor</title><author>Genescà, Anna ; Miró, Rosa ; Rosa Caballin, M. ; Benet, Jordi ; Navarro, Joaquima ; Templado, Cristina ; Bonfill, Xavier ; Egozcue, Josep</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-c52f2e076d57d3327ee41116556eb61f5d5a649b514a29d5044885dfd1bec6d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>560151 - Radiation Effects on Animals- Man</topic><topic>Adult</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL RADIATION EFFECTS</topic><topic>BODY</topic><topic>CHEMOTHERAPY</topic><topic>CHROMOSOMAL ABERRATIONS</topic><topic>Chromosome Aberrations - drug effects</topic><topic>Chromosome Aberrations - radiation effects</topic><topic>Chromosome Banding</topic><topic>CHROMOSOMES</topic><topic>Chromosomes, Human, Pair 1</topic><topic>DELAYED RADIATION EFFECTS</topic><topic>DISEASES</topic><topic>GAMETES</topic><topic>GENETIC EFFECTS</topic><topic>Genetic Markers</topic><topic>GENETIC RADIATION EFFECTS</topic><topic>GERM CELLS</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Kidney Neoplasms - drug therapy</topic><topic>Kidney Neoplasms - radiotherapy</topic><topic>Kidney Neoplasms - therapy</topic><topic>KIDNEYS</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MEDICINE</topic><topic>MUTATIONS</topic><topic>NEOPLASMS</topic><topic>Nephrology. Urinary tract diseases</topic><topic>NUCLEAR MEDICINE</topic><topic>ORGANS</topic><topic>RADIATION EFFECTS</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. 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Cytogenet.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Genescà, Anna</au><au>Miró, Rosa</au><au>Rosa Caballin, M.</au><au>Benet, Jordi</au><au>Navarro, Joaquima</au><au>Templado, Cristina</au><au>Bonfill, Xavier</au><au>Egozcue, Josep</au><aucorp>Universitat Autonoma de Barcelona, Spain</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of a possible constitutional “hot spot” in sperm chromosomes of a patient treated for Wilms' tumor</atitle><jtitle>Cancer Genet. Cytogenet.; (United States)</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>1987-11-01</date><risdate>1987</risdate><volume>29</volume><issue>1</issue><spage>91</spage><epage>96</epage><pages>91-96</pages><issn>0165-4608</issn><eissn>1873-4456</eissn><coden>CGCYDF</coden><abstract>Sperm chromosomes were studied in a man who was treated for Wilms' tumor with radiotherapy (RT) and chemotherapy (CT) 18 years ago. Human pronuclear sperm chromosomes were obtained after penetration of zona-free hamster eggs. Eighty-nine sperm chromosome complements were analyzed; 12.4% of them showed structural anomalies. This percentage was statistically different from the one found in our laboratory for controls (
p<0.05). Five of eleven structurally abnormal metaphases had the same aberration: fission of chromosome #1 with the breakpoint at or near the centromere. Breaks and rearrangements of chromosome #1, often involving the centromere region, are among the most frequent anomalies found in Wilms' tumor cells.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2822226</pmid><doi>10.1016/0165-4608(87)90034-3</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0165-4608 |
| ispartof | Cancer Genet. Cytogenet.; (United States), 1987-11, Vol.29 (1), p.91-96 |
| issn | 0165-4608 1873-4456 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | 560151 - Radiation Effects on Animals- Man Adult Antineoplastic Agents - adverse effects Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BODY CHEMOTHERAPY CHROMOSOMAL ABERRATIONS Chromosome Aberrations - drug effects Chromosome Aberrations - radiation effects Chromosome Banding CHROMOSOMES Chromosomes, Human, Pair 1 DELAYED RADIATION EFFECTS DISEASES GAMETES GENETIC EFFECTS Genetic Markers GENETIC RADIATION EFFECTS GERM CELLS Humans Karyotyping Kidney Neoplasms - drug therapy Kidney Neoplasms - radiotherapy Kidney Neoplasms - therapy KIDNEYS Male Medical sciences MEDICINE MUTATIONS NEOPLASMS Nephrology. Urinary tract diseases NUCLEAR MEDICINE ORGANS RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOINDUCTION RADIOLOGY RADIOTHERAPY SIDE EFFECTS SPERMATOZOA Spermatozoa - ultrastructure THERAPY Tumors of the urinary system Wilms Tumor - drug therapy Wilms Tumor - radiotherapy Wilms Tumor - therapy |
| title | Expression of a possible constitutional “hot spot” in sperm chromosomes of a patient treated for Wilms' tumor |
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