Expression of a possible constitutional “hot spot” in sperm chromosomes of a patient treated for Wilms' tumor

Sperm chromosomes were studied in a man who was treated for Wilms' tumor with radiotherapy (RT) and chemotherapy (CT) 18 years ago. Human pronuclear sperm chromosomes were obtained after penetration of zona-free hamster eggs. Eighty-nine sperm chromosome complements were analyzed; 12.4% of them...

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Veröffentlicht in:	Cancer Genet. Cytogenet.; (United States) 1987-11, Vol.29 (1), p.91-96
Hauptverfasser:	Genescà, Anna, Miró, Rosa, Rosa Caballin, M., Benet, Jordi, Navarro, Joaquima, Templado, Cristina, Bonfill, Xavier, Egozcue, Josep
Format:	Artikel
Sprache:	eng
Schlagworte:	560151 - Radiation Effects on Animals- Man Adult Antineoplastic Agents - adverse effects Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BODY CHEMOTHERAPY CHROMOSOMAL ABERRATIONS Chromosome Aberrations - drug effects Chromosome Aberrations - radiation effects Chromosome Banding CHROMOSOMES Chromosomes, Human, Pair 1 DELAYED RADIATION EFFECTS DISEASES GAMETES GENETIC EFFECTS Genetic Markers GENETIC RADIATION EFFECTS GERM CELLS Humans Karyotyping Kidney Neoplasms - drug therapy Kidney Neoplasms - radiotherapy Kidney Neoplasms - therapy KIDNEYS Male Medical sciences MEDICINE MUTATIONS NEOPLASMS Nephrology. Urinary tract diseases NUCLEAR MEDICINE ORGANS RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOINDUCTION RADIOLOGY RADIOTHERAPY SIDE EFFECTS SPERMATOZOA Spermatozoa - ultrastructure THERAPY Tumors of the urinary system Wilms Tumor - drug therapy Wilms Tumor - radiotherapy Wilms Tumor - therapy
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Zusammenfassung:	Sperm chromosomes were studied in a man who was treated for Wilms' tumor with radiotherapy (RT) and chemotherapy (CT) 18 years ago. Human pronuclear sperm chromosomes were obtained after penetration of zona-free hamster eggs. Eighty-nine sperm chromosome complements were analyzed; 12.4% of them showed structural anomalies. This percentage was statistically different from the one found in our laboratory for controls ( p
ISSN:	0165-4608 1873-4456
DOI:	10.1016/0165-4608(87)90034-3