Double-blind comparisons of slow-release theophylline, ketotifen and placebo for prophylaxis of asthma in young children

Clinical trials of slow-release theophylline and ketotifen as prophylaxis against asthma in 18 young children suggested that both drugs had some efficacy. The theophylline was more effective and produced reduction in salbutamol usage as well as an increase in peak expiratory flow rates. Transient na...

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Veröffentlicht in:	British journal of diseases of the chest 1984, Vol.78 (2), p.163-167
Hauptverfasser:	Stratton, D., Carswell, F., Hughes, A.O., Fysh, W.J., Robinson, Patricia
Format:	Artikel
Sprache:	eng
Schlagworte:	Asthma - prevention & control Biological and medical sciences Child Child, Preschool Clinical Trials as Topic Delayed-Action Preparations Double-Blind Method Female Humans Infant Ketotifen - therapeutic use Male Medical sciences Pharmacology. Drug treatments Respiratory system Theophylline - therapeutic use
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Zusammenfassung:	Clinical trials of slow-release theophylline and ketotifen as prophylaxis against asthma in 18 young children suggested that both drugs had some efficacy. The theophylline was more effective and produced reduction in salbutamol usage as well as an increase in peak expiratory flow rates. Transient nausea and vomiting was commoner during theophylline treatment but did not usually necessitate discontinuing therapy.
ISSN:	0007-0971 1878-2426
DOI:	10.1016/0007-0971(84)90117-7