One-dimensional and two-dimensional nuclear magnetic resonance studies of the reaction of phenyldichloroarsine with glutathione

14C-labeled phenyldichloroarsine (PDA) enters the red blood cell and forms a 1:2 adduct with intracellular glutathione. Upon gel filtration of the hemolysate, [ 14C]PDA was recovered with the glutathione-containing fractions. One-dimensional and two-dimensional nuclear magnetic resonance spectroscop...

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Veröffentlicht in:	Arch. Biochem. Biophys.; (United States) 1987-09, Vol.257 (2), p.293-301
Hauptverfasser:	Dill, Kilian, Adams, Earle R., O'Connor, Richard J., Chong, Steven, McGown, Evelyn L.
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques 560300 - Chemicals Metabolism & Toxicology ADDUCTS ARSENIC Arsenicals - blood BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL MATERIALS BLOOD BLOOD CELLS BODY FLUIDS CARBON 14 COMPOUNDS Carbon Radioisotopes Chromatography, Gel DRUGS ELEMENTS ERYTHROCYTES Fundamental and applied biological sciences. Psychology GLUTATHIONE Glutathione - blood Humans Interactions. Associations Intermolecular phenomena ISOTOPE APPLICATIONS LABELLED COMPOUNDS MAGNETIC RESONANCE Magnetic Resonance Spectroscopy - methods MATERIALS Molecular biophysics Molecular Conformation MOLECULAR STRUCTURE NUCLEAR MAGNETIC RESONANCE ORGANIC COMPOUNDS PEPTIDES POLYPEPTIDES PROTEINS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOPROTECTIVE SUBSTANCES RESONANCE SEMIMETALS STEREOCHEMISTRY TRACER TECHNIQUES
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Beschreibung
Zusammenfassung:	14C-labeled phenyldichloroarsine (PDA) enters the red blood cell and forms a 1:2 adduct with intracellular glutathione. Upon gel filtration of the hemolysate, [ 14C]PDA was recovered with the glutathione-containing fractions. One-dimensional and two-dimensional nuclear magnetic resonance spectroscopy were used to confirm the structure of the adduct and elucidate its stereochemistry, stability, and reactivity.
ISSN:	0003-9861 1096-0384
DOI:	10.1016/0003-9861(87)90569-8