Structural and dynamical characterization of piroxicam by 1H- and 13C-NMR relaxation studies

Carbon spin-lattice relaxation rates of an anti-inflammatory drug piroxicam have been measured. These results have been used in determining the reorientational rates of the proton carbon vectors. An analysis of internal motions within the pyridinyl moiety of piroxicam was carried out. Selective proton-carbon nuclear Overhauser effect (NOE) measurements were made in order to determine the solution structure of piroxicam. The effect of indirect NOE arising from exchangeable protons has been analyzed and considered.