Reaction of alkylcobalamins with thiols

Carbon-13 NMR spectroscopy and phosphorus-31 NMR spectroscopy have been used to study the reaction of several alkylcobalamins with 2-mercaptoethanol. At alkaline pH, when the thiol is deprotonated, the alkyl-transfer reactions involve a nucleophilic attack of the thiolate anion on the Co-methylene c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemistry (Easton) 1987-07, Vol.26 (15), p.4723-4727
Hauptverfasser:	Hogenkamp, Harry P. C, Bratt, Gerald T, Kotchevar, Ann T
Format:	Artikel
Sprache:	eng
Schlagworte:	550601 - Medicine- Unsealed Radionuclides in Diagnostics Alkylation alkylcobalamin Analytical, structural and metabolic biochemistry BIOCHEMICAL REACTION KINETICS Biological and medical sciences CARBON 13 CARBON ISOTOPES CHEMICAL REACTIONS COBALT COMPOUNDS COENZYMES Coenzymes, vitamins Dithiothreitol EVEN-ODD NUCLEI Fundamental and applied biological sciences. Psychology HEAVY WATER HYDROGEN COMPOUNDS ISOTOPES KINETICS LIGHT NUCLEI MAGNETIC RESONANCE Magnetic Resonance Spectroscopy - methods Mercaptoethanol METHYLATION NUCLEAR MAGNETIC RESONANCE NUCLEI ODD-EVEN NUCLEI ORGANIC COMPOUNDS ORGANIC SULFUR COMPOUNDS Other biological molecules OXYGEN COMPOUNDS PH VALUE PHOSPHORUS 31 PHOSPHORUS ISOTOPES RADIOLOGY AND NUCLEAR MEDICINE REACTION KINETICS RESONANCE STABLE ISOTOPES Structure-Activity Relationship sulfhydryl groups THIOLS TRANSITION ELEMENT COMPOUNDS Vitamin B 12 - analogs & derivatives WATER
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!