Histamine levels and cardiovascular responses during splenectomy and splenorenal shunt formation in a patient with systemic mastocytosis

Summary Systemic mastocytosis is a rare disorder characterised by the infiltration of many tissues by abnormal numbers of mast cells. Life‐threatening episodes of bronchospasm and hypotension are common in response to a variety of triggers which cause mast cell degranulation. We present the case his...

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Veröffentlicht in:Anaesthesia 1987-08, Vol.42 (8), p.861-867
Hauptverfasser: SMITH, G. B., GUSBERG, R. J., JORDAN, R. H., KIM, B.
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Sprache:eng
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Zusammenfassung:Summary Systemic mastocytosis is a rare disorder characterised by the infiltration of many tissues by abnormal numbers of mast cells. Life‐threatening episodes of bronchospasm and hypotension are common in response to a variety of triggers which cause mast cell degranulation. We present the case history of a patient with severe mast cell disease who successfully underwent splenectomy and portocaval anastomosis. Peri‐operative therapy was directed towards mast cell stabilisation, and histamine‐releasing drugs were avoided. Cardiovascular data, together with blood histamine levels and thrombin times, indicated that mast cell degranulation did not occur. A review of the current literature concerning mast cell disease as it relates to anaesthesia is presented and suggestions for the safe management of such cases are given.
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.1987.tb04112.x