Prenatal ACTH and corticosterone: Effects on reproduction in male mice

Injections of ACTH or corticosterone into late pregnant mice from Days 14 to 21 did not alter testes weights or feminine copulatory behavior of male offspring in adulthood. However masculine copulatory behavior was significantly reduced. Because ACTH does not cross the placenta, alterations in sexua...

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Veröffentlicht in:	Physiology & behavior 1984, Vol.32 (1), p.135-137
Hauptverfasser:	Politch, Joseph A., Herrenkohl, Lorraine Roth
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic Hormone - pharmacology Animals Biological and medical sciences Corticosterone - pharmacology Female Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Male Male mice Mammalian male genital system Mice - physiology Mice, Inbred Strains Pregnancy Prenatal ACTH Prenatal corticosterone Prenatal Exposure Delayed Effects Reproduction Reproduction - drug effects Testis - growth & development Vertebrates: reproduction
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Beschreibung
Zusammenfassung:	Injections of ACTH or corticosterone into late pregnant mice from Days 14 to 21 did not alter testes weights or feminine copulatory behavior of male offspring in adulthood. However masculine copulatory behavior was significantly reduced. Because ACTH does not cross the placenta, alterations in sexual behavior of male offspring were probably mediated by maternal corticosteroid secretion.
ISSN:	0031-9384 1873-507X
DOI:	10.1016/0031-9384(84)90085-4