Formation of a Vasopressor Substance in the Incubated Serum of Patients with Various Hypertensive Diseases

MAEBASHI, M. and YOSHINAGA, K. Formation of a Vasopressor Substance in the Incubated Serum in Patients with Various Hypertensive Diseases. Tohoku J. exp. Med., 1984, 142 (2), 173-182 - A vasoactive substance was produced in serum when incubated at 37°C. This substance differed from other known vasoactive agents. It was a phospholipid and caused an elevation in blood pressure by its direct vasoconstriction. This pressor substance increased in the incubated sera of patients with essential hypertension and in spontaneously hypertensive rats. But it was significantly low in humans and dogs in anephric states. These results suggest that the pressor substance participates in the pressor mechanism of essential hypertension and its production is closely related to the kidney.