Interleukin-3 supports growth of mouse pre-B-cell clones in vitro
Study of the differentiation of immunoglobulin-producing B lymphocytes has been hampered by the inability to maintain homogeneous populations of precursor cells in vitro . We describe here that interleukin-3 supports the growth of freshly isolated fetal liver pre-B cells and the long-term culture of...
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| Veröffentlicht in: | Nature (London) 1984-05, Vol.309 (5964), p.126-131 |
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| container_end_page | 131 |
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| container_issue | 5964 |
| container_start_page | 126 |
| container_title | Nature (London) |
| container_volume | 309 |
| creator | Palacios, Ronald Henson, Geoffrey Steinmetz, Michael McKearn, John P |
| description | Study of the differentiation of immunoglobulin-producing B lymphocytes has been hampered by the inability to maintain homogeneous populations of precursor cells
in vitro
. We describe here that interleukin-3 supports the growth of freshly isolated fetal liver pre-B cells and the long-term culture of interleukin-3 dependent pre-B-cell clones that can be induced to mature into antibody secreting cells
in vitro
. |
| doi_str_mv | 10.1038/309126a0 |
| format | Article |
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in vitro
. We describe here that interleukin-3 supports the growth of freshly isolated fetal liver pre-B cells and the long-term culture of interleukin-3 dependent pre-B-cell clones that can be induced to mature into antibody secreting cells
in vitro
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in vitro
. We describe here that interleukin-3 supports the growth of freshly isolated fetal liver pre-B cells and the long-term culture of interleukin-3 dependent pre-B-cell clones that can be induced to mature into antibody secreting cells
in vitro
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in vitro
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| ispartof | Nature (London), 1984-05, Vol.309 (5964), p.126-131 |
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| language | eng |
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| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Animals Antigens, Surface - analysis B-Lymphocytes - drug effects B-Lymphocytes - immunology Biological and medical sciences Cell Differentiation Cell Line Clone Cells DNA Replication - drug effects Epitopes - analysis Fundamental and applied biological sciences. Psychology Fundamental immunology General aspects. Ontogeny. Phylogeny Genes Humanities and Social Sciences Immunobiology Immunoglobulin kappa-Chains - genetics Immunoglobulin M - analysis Immunoglobulin mu-Chains - genetics Interleukin-3 Lymphocyte Activation Lymphokines - pharmacology Mice Mice, Nude multidisciplinary Phenotype Science Science (multidisciplinary) |
| title | Interleukin-3 supports growth of mouse pre-B-cell clones in vitro |
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