Interleukin-3 supports growth of mouse pre-B-cell clones in vitro

Study of the differentiation of immunoglobulin-producing B lymphocytes has been hampered by the inability to maintain homogeneous populations of precursor cells in vitro . We describe here that interleukin-3 supports the growth of freshly isolated fetal liver pre-B cells and the long-term culture of...

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Veröffentlicht in:	Nature (London) 1984-05, Vol.309 (5964), p.126-131
Hauptverfasser:	Palacios, Ronald, Henson, Geoffrey, Steinmetz, Michael, McKearn, John P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Surface - analysis B-Lymphocytes - drug effects B-Lymphocytes - immunology Biological and medical sciences Cell Differentiation Cell Line Clone Cells DNA Replication - drug effects Epitopes - analysis Fundamental and applied biological sciences. Psychology Fundamental immunology General aspects. Ontogeny. Phylogeny Genes Humanities and Social Sciences Immunobiology Immunoglobulin kappa-Chains - genetics Immunoglobulin M - analysis Immunoglobulin mu-Chains - genetics Interleukin-3 Lymphocyte Activation Lymphokines - pharmacology Mice Mice, Nude multidisciplinary Phenotype Science Science (multidisciplinary)
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Beschreibung
Zusammenfassung:	Study of the differentiation of immunoglobulin-producing B lymphocytes has been hampered by the inability to maintain homogeneous populations of precursor cells in vitro . We describe here that interleukin-3 supports the growth of freshly isolated fetal liver pre-B cells and the long-term culture of interleukin-3 dependent pre-B-cell clones that can be induced to mature into antibody secreting cells in vitro .
ISSN:	0028-0836 1476-4687
DOI:	10.1038/309126a0