Fragile-X Chromosome Associated With Primary Learning Disability
The occurrence of a fragile site in the X chromosome, associated with X-linked mental retardation and, occasionally, autism, has been labeled Fragile-X Syndrome. This case study describes a patient with a documented, specific learning disability in association with the Fragile-X chromosome. He has a...
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| Veröffentlicht in: | Journal of the American Academy of Child and Adolescent Psychiatry 1987-07, Vol.26 (4), p.589-592 |
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| container_end_page | 592 |
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| container_issue | 4 |
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| container_title | Journal of the American Academy of Child and Adolescent Psychiatry |
| container_volume | 26 |
| creator | GOLDFINE, PETER E. McPHERSON, PETER M. HARDESTY, VAUGHN A. HEATH, G. ADAIR BEAUREGARD, LAURENT J. BAKER, ARLENE A. |
| description | The occurrence of a fragile site in the X chromosome, associated with X-linked mental retardation and, occasionally, autism, has been labeled Fragile-X Syndrome. This case study describes a patient with a documented, specific learning disability in association with the Fragile-X chromosome. He has a family history of two retarded first cousins, one of whom also has diagnosed Fragile-X syndrome. This single case study suggests that there may be an association of the Fragile-X abnormality with dyslexia or primary learning disability, suggesting a genetic etiology for primary dyslexia. |
| doi_str_mv | 10.1097/00004583-198707000-00024 |
| format | Article |
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This single case study suggests that there may be an association of the Fragile-X abnormality with dyslexia or primary learning disability, suggesting a genetic etiology for primary dyslexia.</description><identifier>ISSN: 0890-8567</identifier><identifier>EISSN: 1527-5418</identifier><identifier>DOI: 10.1097/00004583-198707000-00024</identifier><identifier>PMID: 3654517</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; autism ; dyslexia ; Fragile X Syndrome - complications ; Fragile X Syndrome - genetics ; Fragile-X Syndrome ; Humans ; learning disability ; Learning Disorders - complications ; Learning Disorders - genetics ; Male ; Pedigree ; Sex Chromosome Aberrations - complications</subject><ispartof>Journal of the American Academy of Child and Adolescent Psychiatry, 1987-07, Vol.26 (4), p.589-592</ispartof><rights>1987 The American Academy of Child and Adolescent Psychiatry</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-1561b8f62be00a17dcefdeb0e3ec4f05d70294d7e8dd5753fc4c95bd0e5ff0ae3</citedby><cites>FETCH-LOGICAL-c369t-1561b8f62be00a17dcefdeb0e3ec4f05d70294d7e8dd5753fc4c95bd0e5ff0ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1097/00004583-198707000-00024$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3654517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GOLDFINE, PETER E.</creatorcontrib><creatorcontrib>McPHERSON, PETER M.</creatorcontrib><creatorcontrib>HARDESTY, VAUGHN A.</creatorcontrib><creatorcontrib>HEATH, G. 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This single case study suggests that there may be an association of the Fragile-X abnormality with dyslexia or primary learning disability, suggesting a genetic etiology for primary dyslexia.</description><subject>Adult</subject><subject>autism</subject><subject>dyslexia</subject><subject>Fragile X Syndrome - complications</subject><subject>Fragile X Syndrome - genetics</subject><subject>Fragile-X Syndrome</subject><subject>Humans</subject><subject>learning disability</subject><subject>Learning Disorders - complications</subject><subject>Learning Disorders - genetics</subject><subject>Male</subject><subject>Pedigree</subject><subject>Sex Chromosome Aberrations - complications</subject><issn>0890-8567</issn><issn>1527-5418</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkN9LwzAQx4Moc07_BKFPvlWTtmnSN-d0Kgz0QdG3kCaXLdI2M-mE_fdGO_fqwXEc971fH4QSgi8JrtgVjlZQnqek4gyzmKXRs-IAjQnNWEoLwg_RGPMKp5yW7BidhPARJYRxPkKjvKQFJWyMrudeLm0D6XsyW3nXuuBaSKYhOGVlDzp5s_0qefa2lX6bLED6znbL5NYGWdvG9ttTdGRkE-BsFyfodX73MntIF0_3j7PpIlV5WfUpoSWpuSmzGjCWhGkFRkONIQdVGEw1w1lVaAZca8poblShKlprDNQYLCGfoIth7tq7zw2EXrQ2KGga2YHbBMEJzmlZZlHIB6HyLgQPRqyH6wXB4gee-IMn9vDEL7zYer7bsalb0PvGHa1YvxnqEB_9suBFUBY6Bdp6UL3Qzv6_5Bua1H7k</recordid><startdate>19870701</startdate><enddate>19870701</enddate><creator>GOLDFINE, PETER E.</creator><creator>McPHERSON, PETER M.</creator><creator>HARDESTY, VAUGHN A.</creator><creator>HEATH, G. ADAIR</creator><creator>BEAUREGARD, LAURENT J.</creator><creator>BAKER, ARLENE A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870701</creationdate><title>Fragile-X Chromosome Associated With Primary Learning Disability</title><author>GOLDFINE, PETER E. ; McPHERSON, PETER M. ; HARDESTY, VAUGHN A. ; HEATH, G. ADAIR ; BEAUREGARD, LAURENT J. ; BAKER, ARLENE A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-1561b8f62be00a17dcefdeb0e3ec4f05d70294d7e8dd5753fc4c95bd0e5ff0ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adult</topic><topic>autism</topic><topic>dyslexia</topic><topic>Fragile X Syndrome - complications</topic><topic>Fragile X Syndrome - genetics</topic><topic>Fragile-X Syndrome</topic><topic>Humans</topic><topic>learning disability</topic><topic>Learning Disorders - complications</topic><topic>Learning Disorders - genetics</topic><topic>Male</topic><topic>Pedigree</topic><topic>Sex Chromosome Aberrations - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GOLDFINE, PETER E.</creatorcontrib><creatorcontrib>McPHERSON, PETER M.</creatorcontrib><creatorcontrib>HARDESTY, VAUGHN A.</creatorcontrib><creatorcontrib>HEATH, G. ADAIR</creatorcontrib><creatorcontrib>BEAUREGARD, LAURENT J.</creatorcontrib><creatorcontrib>BAKER, ARLENE A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Child and Adolescent Psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GOLDFINE, PETER E.</au><au>McPHERSON, PETER M.</au><au>HARDESTY, VAUGHN A.</au><au>HEATH, G. 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This single case study suggests that there may be an association of the Fragile-X abnormality with dyslexia or primary learning disability, suggesting a genetic etiology for primary dyslexia.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>3654517</pmid><doi>10.1097/00004583-198707000-00024</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0890-8567 |
| ispartof | Journal of the American Academy of Child and Adolescent Psychiatry, 1987-07, Vol.26 (4), p.589-592 |
| issn | 0890-8567 1527-5418 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Journals@Ovid Complete |
| subjects | Adult autism dyslexia Fragile X Syndrome - complications Fragile X Syndrome - genetics Fragile-X Syndrome Humans learning disability Learning Disorders - complications Learning Disorders - genetics Male Pedigree Sex Chromosome Aberrations - complications |
| title | Fragile-X Chromosome Associated With Primary Learning Disability |
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