Fragile-X Chromosome Associated With Primary Learning Disability

The occurrence of a fragile site in the X chromosome, associated with X-linked mental retardation and, occasionally, autism, has been labeled Fragile-X Syndrome. This case study describes a patient with a documented, specific learning disability in association with the Fragile-X chromosome. He has a family history of two retarded first cousins, one of whom also has diagnosed Fragile-X syndrome. This single case study suggests that there may be an association of the Fragile-X abnormality with dyslexia or primary learning disability, suggesting a genetic etiology for primary dyslexia.