Effect of copper sulphate on the rate of afferent discharge in the gastric branch of the vagus nerve in the rat

The afferent nerve activity was recorded from a nerve filament isolated from the peripheral cut end of the gastric branch of the vagus nerve. The gastric perfusion of 4 ml of two different concentrations (0.04% and 0.08%) of CuSO 4 solution provoked an increase in afferent activity. The stimulating...

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Veröffentlicht in:	Neuroscience letters 1987-09, Vol.80 (1), p.71-74
Hauptverfasser:	Niijima, Akira, Jiang, Zheng-Yao, Daunton, Nancy G., Fox, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Afferent discharge Animals Biological and medical sciences Copper - pharmacology Copper Sulfate Copper sulphate Electrophysiology Emesis Fundamental and applied biological sciences. Psychology Gastric branch Gastric perfusion Male Rats Rats, Inbred Strains Space life sciences Stomach Vagus nerve Vagus Nerve - drug effects Vagus Nerve - physiology Vertebrates: digestive system
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Zusammenfassung:	The afferent nerve activity was recorded from a nerve filament isolated from the peripheral cut end of the gastric branch of the vagus nerve. The gastric perfusion of 4 ml of two different concentrations (0.04% and 0.08%) of CuSO 4 solution provoked an increase in afferent activity. The stimulating effect of the 0.08% solution was stronger than that of the 0.04% solution, and lasted for a longer period of time. The observations suggest a possible mechanism by which CuSO 4 elicits emesis.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(87)90497-6