Demonstration, in the black mouse, of a protein linked to the process of cancer formation in B16 melanoma

One supplementary protein (PI = 3,5; molecular weight 70 000) was detected by electrofocusing in sera of black male and female Mice bearing the B16 melanoma. This protein was also present in the cytoplasmic fraction of tumoral cells, but not in the membrane fraction and cytoplasmic fractions of hepatic and spleen cells. The cancerous Mice presented an augmentation of the total sera proteins compared to the controls.