Relaxation of isolated guinea pig trachea, bronchi and pulmonary arteries produced by vasoactive intestinal peptide (VIP)

Vasoactive intestinal peptide (VIP) relaxed isolated guinea pig airways contracted with carbamylcholine and isolated pulmonary arteries contracted with prostaglandin F 2α. VIP was more potent as a relaxant agonist on trachea than on bronchi but was equipotent on the main and branch pulmonary artery....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 1984-02, Vol.98 (2), p.279-284
Hauptverfasser:	Hand, James M., Laravuso, Raymond B., Will, James A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Air breathing Animals Biological and medical sciences Brochi Bronchi Fundamental and applied biological sciences. Psychology Guinea Pigs In Vitro Techniques Male Muscle Contraction - drug effects Muscle Relaxation - drug effects Muscle, Smooth - physiology Muscle, Smooth, Vascular - physiology Pulmonary Artery Pulmonary smooth muscle Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Trachea Vasoactive intestinal peptide Vasoactive Intestinal Peptide - pharmacology Vertebrates: respiratory system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Vasoactive intestinal peptide (VIP) relaxed isolated guinea pig airways contracted with carbamylcholine and isolated pulmonary arteries contracted with prostaglandin F 2α. VIP was more potent as a relaxant agonist on trachea than on bronchi but was equipotent on the main and branch pulmonary artery. The VIP-induced relaxation of either airway or artery segments was not altered by pretreatment of animals with reserpine or pretreatment of isolated tissues with propranolol, metiamide, indomethacin or theophylline. These results are consistent with a direct relaxant effect by VIP in guinea pig lung.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(84)90602-2