Hypomethylation of DNA in pathological conditions of the human prostate

The overall 5-methylcytosine content of DNA from normal, benign hyperplastic, and neoplastic human prostate tissue was analyzed. DNA methylation levels were significantly lower in prostates with benign prostatic hyperplasia and metastatic tumors. In contrast, nonmetastatic prostate tumor DNA had a 5...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1987-10, Vol.47 (20), p.5274-5276
Hauptverfasser:	BEDFORD, M. T, VAN HELDEN, P. D
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine Adult Aged Aged, 80 and over Biological and medical sciences Cytosine - analogs & derivatives Cytosine - analysis DNA - metabolism Humans Male Mathematics Medical sciences Methylation Nephrology. Urinary tract diseases Prostatic Hyperplasia - genetics Prostatic Neoplasms - genetics Tumors of the urinary system Urinary tract. Prostate gland
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Zusammenfassung:	The overall 5-methylcytosine content of DNA from normal, benign hyperplastic, and neoplastic human prostate tissue was analyzed. DNA methylation levels were significantly lower in prostates with benign prostatic hyperplasia and metastatic tumors. In contrast, nonmetastatic prostate tumor DNA had a 5-methylcytosine content essentially the same as in normal tissue. The results suggest a correlation between hypomethylation and metastatic capacity.
ISSN:	0008-5472 1538-7445