Metabolic changes in the psoriatic lesion during therapy

SUMMARY Three marker enzymes were measured during treatment of psoriatic plaques with two different therapies. During treatment with clobetasol propionate the epidermal enzymes (acid phosphatase and glucose‐6‐phosphate dehydrogenase) returned to normal within 14 days whereas capillary alkaline phosp...

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Veröffentlicht in:	British journal of dermatology (1951) 1984-04, Vol.110 (4), p.411-415
Hauptverfasser:	VAN DE KERKHOF, P. C. M., FLEUREN, ERNA, VAN RENNES, HELGA, MIER, P.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Phosphatase - metabolism Alkaline Phosphatase - metabolism Betamethasone - analogs & derivatives Biological and medical sciences Clobetasol - analogs & derivatives Clobetasol - therapeutic use Dermatology Epidermis - enzymology Glucosephosphate Dehydrogenase - metabolism Humans Medical sciences Photochemotherapy Psoriasis - drug therapy Psoriasis - enzymology Psoriasis. Parapsoriasis. Lichen PUVA Therapy Time Factors
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Beschreibung
Zusammenfassung:	SUMMARY Three marker enzymes were measured during treatment of psoriatic plaques with two different therapies. During treatment with clobetasol propionate the epidermal enzymes (acid phosphatase and glucose‐6‐phosphate dehydrogenase) returned to normal within 14 days whereas capillary alkaline phosphatase remained at the original level. By contrast, all three marker enzymes reverted to normal at the same tempo during PUVA therapy, reaching the control range after 4–8 weeks.
ISSN:	0007-0963 1365-2133
DOI:	10.1111/j.1365-2133.1984.tb04655.x