Design of New Antidepressants, 4-Anilinopyrimidine Derivatives, Based on Quantitative Structure-Activity Relationships

A quantitative structure-activity relationship formulated for 59 4-anilinopyrimidines inhibiting reserpine-induced ptosis was applied to the design of new, more active, antidepressant compounds. The utility of correlation equations in designing new congeners is discussed and the designed compounds s...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1987/04/25, Vol.35(4), pp.1452-1459
Hauptverfasser:	WATANABE, HIDETOSHI, MIYAMOTO, SHUICHI, YOSHIMOTO, MASAFUMI, KAMIOKA, TOSHIHARU, NAKAYAMA, ISAO, KOBAYASHI, TAKASHI, HONDA, TAKEO
Format:	Artikel
Sprache:	eng
Schlagworte:	4-anilinopyrimidine antidepressant Antidepressive Agents - chemical synthesis Biological and medical sciences Chemistry, Pharmaceutical General pharmacology Medical sciences Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Pyrimidines - chemical synthesis Pyrimidines - pharmacology quantitative structure-activity relationship reserpine-induced ptosis Structure-Activity Relationship
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Zusammenfassung:	A quantitative structure-activity relationship formulated for 59 4-anilinopyrimidines inhibiting reserpine-induced ptosis was applied to the design of new, more active, antidepressant compounds. The utility of correlation equations in designing new congeners is discussed and the designed compounds synthesized show the most active group of the anilinopyrimidines.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.35.1452