Benzoylthiocholine Derivatives as Substrates for Pseudocholinesterase : Synthesis and Application

Substituted benzoylthiocholines were synthesized and their application as reagents for clinical measurement of pseudocholinesterase was investigated. Among 21 compounds, 2, 3-dimethoxybenzoylthiocholine (19b) was found to be an excellent substrate for the measurement of the enzyme. The procedure was...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1987/04/25, Vol.35(4), pp.1491-1496
Hauptverfasser:	YAMADA, MAGOHEI, MARUI, YOJI, HAYASHI, CHOZO, TAKEMURA, SHOJI
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Benzoylcholine - analogs & derivatives Benzoylcholine - chemical synthesis Biological and medical sciences Butyrylcholinesterase - analysis Choline - analogs & derivatives Cholinesterases - analysis clinical test reagent colorimetry Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Humans Hydrolases Indicators and Reagents Kinetics pseudo-cholinesterase substituted benzoylthiocholine Substrate Specificity synthetic substrate
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Beschreibung
Zusammenfassung:	Substituted benzoylthiocholines were synthesized and their application as reagents for clinical measurement of pseudocholinesterase was investigated. Among 21 compounds, 2, 3-dimethoxybenzoylthiocholine (19b) was found to be an excellent substrate for the measurement of the enzyme. The procedure was simple and self-hydrolysis of the substrate at the optimum pH of the enzyme was minimal.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.35.1491