SYNTHESIS OF PSEUDOTRISACCHARIDES RELATED TO RIBOSTAMYCIN

The three protected sisamine derivatives 2i, 2j and 3, with a free 5-hydroxyl group, have been synthesized. Glycosylation at the 5 position with various pentofuranose derivatives yielded after deprotection of the 6a-i ribostamycin related aminoglycoside. These pseudotrisaccharides showed only low an...

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Veröffentlicht in:	Journal of antibiotics 1984, Vol.37(2), pp.150-158
Hauptverfasser:	GIRODEAU, JEAN-MARL, PINEAU, ROLAND, MASSON, MARYSE, GOFFIC, FRANCOIS LE
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Medical sciences Oligosaccharides - chemical synthesis Pharmacology. Drug treatments Ribostamycin - chemical synthesis Trisaccharides - chemical synthesis
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Zusammenfassung:	The three protected sisamine derivatives 2i, 2j and 3, with a free 5-hydroxyl group, have been synthesized. Glycosylation at the 5 position with various pentofuranose derivatives yielded after deprotection of the 6a-i ribostamycin related aminoglycoside. These pseudotrisaccharides showed only low antibacterial activities with respect to the parent compounds.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.37.150