Paramagnetic metalloporphyrins as potential contrast agents in NMR imaging

Several water-soluble paramagnetic metalloporphyrins were found to increase significantly the relaxation rate (1/ T 1) of water. Such compounds are known to be selectively retained by tumors in animals, and consequently we identify them as potential contrast agents for tumors in NMR imaging.

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Bibliographische Detailangaben
Veröffentlicht in:	FEBS letters 1984-03, Vol.168 (1), p.70-74
Hauptverfasser:	Chen, Chi-wan, Cohen, Jack S., Myers, Charles E., Sohn, Miriam
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Contrast Media Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Spectroscopy - methods Medical sciences Metalloporphyrin Metalloporphyrins NMR contrast agent NMR imaging Paramagnetic reagent Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	Several water-soluble paramagnetic metalloporphyrins were found to increase significantly the relaxation rate (1/ T 1) of water. Such compounds are known to be selectively retained by tumors in animals, and consequently we identify them as potential contrast agents for tumors in NMR imaging.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(84)80208-2