METABOLIC PRODUCTS OF MICROORGANISMS. 224: BAFILOMYCINS, A NEW GROUP OF MACROLIDE ANTIBIOTICS PRODUCTION, ISOLATION, CHEMICAL STRUCTURE AND BIOLOGICAL ACTIVITY

The bafilomycins A1, A2, B1, B2, C1 and C2, a new type of macrolide antibiotics with a 16-membered lactone ring, were isolated from the fermentation broth of three Streptomyces griseus strains (TÜ 1922, TÜ 2437, TÜ 2599) by ethyl acetate extraction and column chromatography on silica gel. The bafilo...

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Veröffentlicht in:	Journal of antibiotics 1984, Vol.37(2), pp.110-117
Hauptverfasser:	WERNER, GERHARD, HAGENMAIER, HANSPAUL, DRAUTZ, HANNELORE, BAUMGARTNER, ANGELIKA, ZÄHNER, HANS
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antifungal Agents - biosynthesis Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Bacteria - drug effects bafilomycin Chemical Phenomena Chemistry Fermentation Fungi - drug effects Lactones - isolation & purification Macrolides Streptomyces griseus Streptomyces griseus - metabolism
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Zusammenfassung:	The bafilomycins A1, A2, B1, B2, C1 and C2, a new type of macrolide antibiotics with a 16-membered lactone ring, were isolated from the fermentation broth of three Streptomyces griseus strains (TÜ 1922, TÜ 2437, TÜ 2599) by ethyl acetate extraction and column chromatography on silica gel. The bafilomycins exhibit activity against Gram-positive bacteria and fungi. Physico-chemical data, chemical structures and biological activities are reported.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.37.110