Enzyme-linked immunosorbent assay for IgG antibodies to Epstein-Barr virus-associated early antigens and viral capsid antigen

An enzyme-linked immunosorbent assay has been developed for the detection of IgG antibodies to Epstein-Barr virus-associated early antigens and late antigens including the viral capsid antigen. The antibody titers of human sera determined in this way correlate well with those by indirect immunofluor...

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Veröffentlicht in:	Journal of immunological methods 1984-03, Vol.67 (2), p.225-233
Hauptverfasser:	Dölken, Gottfried, Weitzmann, Ulrike, Boldt, Carola, Bitzer, Michael, Brugger, Wolfram, Löhr, Georg W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Viral - immunology Biological and medical sciences Capsid - immunology Cell Line Cell Nucleus - immunology EBV-associated antigens ELISA Enzyme-Linked Immunosorbent Assay Epstein-Barr virus Epstein-Barr Virus Nuclear Antigens Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Herpesvirus 4, Human - immunology Humans IgG Immunoenzyme Techniques Immunoglobulin G - analysis Microbiology Techniques used in virology Virology
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Zusammenfassung:	An enzyme-linked immunosorbent assay has been developed for the detection of IgG antibodies to Epstein-Barr virus-associated early antigens and late antigens including the viral capsid antigen. The antibody titers of human sera determined in this way correlate well with those by indirect immunofluorescence. ELISA was more sensitive than the IF method. The assays described may be used for rapid and sensitive diagnosis of EBV-related diseases. In addition, the ELISA will be useful for the determination of antibody titers to isolated EBV-associated antigens, e.g., purified components of the EA complex.
ISSN:	0022-1759 1872-7905
DOI:	10.1016/0022-1759(84)90463-0